000161883 001__ 161883
000161883 005__ 20251017144622.0
000161883 0247_ $$2doi$$a10.3389/fbioe.2025.1454903
000161883 0248_ $$2sideral$$a144544
000161883 037__ $$aART-2025-144544
000161883 041__ $$aeng
000161883 100__ $$aSawadkar, Prasad
000161883 245__ $$aInnovative hydrogels in cutaneous wound healing: current status and future perspectives
000161883 260__ $$c2025
000161883 5060_ $$aAccess copy available to the general public$$fUnrestricted
000161883 5203_ $$aChronic wounds pose a substantial burden on healthcare systems, necessitating innovative tissue engineering strategies to enhance clinical outcomes. Hydrogels, both of natural and synthetic origin, have emerged as versatile biomaterials for wound management due to their structural adaptability, biocompatibility, and tunable physicochemical properties. Their hydrophilic nature enables efficient nutrient transport, waste removal, and cellular integration, while their malleability facilitates application to deep and irregular wounds, providing an optimal microenvironment for cell adhesion, proliferation, and differentiation. Extracellular matrix (ECM)- based hydrogels retain bioactive molecules that support cellular infiltration, immune modulation, and tissue remodelling, making them highly effective scaffolds for growth factor delivery and regenerative therapies. Additionally, their injectability and potential for in situ polymerization enable minimally invasive applications, allowing on-demand gelation at target sites. By modifying their mechanical properties through crosslinking, hydrogels can achieve enhanced structural stability, prolonged degradation control, and improved surgical handling, optimizing their functionality in dynamic wound environments. This review outlines current approaches to skin tissue engineering, examining the biomaterials employed in hydrogel design, their limitations, and their interactions with host tissues. Furthermore, it highlights the emerging potential of functionalized injectable hydrogels, particularly those engineered for controlled drug release, enhanced bioactivity, and patient-specific therapeutic applications. These hydrogels offer a transformative platform for advanced wound care and regenerative medicine.
000161883 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/RYC2021-033490-I$$9info:eu-repo/grantAgreement/ES/NextGenerationEU/PRTR
000161883 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000161883 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000161883 700__ $$aLali, Ferdinand
000161883 700__ $$0(orcid)0000-0001-7062-9099$$aGarcia-Gareta, Elena$$uUniversidad de Zaragoza
000161883 700__ $$aGarrido, Beatriz Gil
000161883 700__ $$aChaudhry, Abdullah
000161883 700__ $$aMatharu, Priya
000161883 700__ $$aKyriakidis, Christos
000161883 700__ $$aGreco, Karin
000161883 7102_ $$15001$$2065$$aUniversidad de Zaragoza$$bDpto. Ciencia Tecnol.Mater.Fl.$$cÁrea Cienc.Mater. Ingen.Metal.
000161883 773__ $$g13 (2025), 24 pp.$$pFront. Bioeng. Biotechnol.$$tFrontiers in Bioengineering and Biotechnology$$x2296-4185
000161883 8564_ $$s2602543$$uhttps://zaguan.unizar.es/record/161883/files/texto_completo.pdf$$yVersión publicada
000161883 8564_ $$s2107979$$uhttps://zaguan.unizar.es/record/161883/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000161883 909CO $$ooai:zaguan.unizar.es:161883$$particulos$$pdriver
000161883 951__ $$a2025-10-17-14:22:10
000161883 980__ $$aARTICLE