000161904 001__ 161904
000161904 005__ 20251017144639.0
000161904 0247_ $$2doi$$a10.3390/ani15111592
000161904 0248_ $$2sideral$$a144472
000161904 037__ $$aART-2025-144472
000161904 041__ $$aeng
000161904 100__ $$aRosado, Belén$$uUniversidad de Zaragoza
000161904 245__ $$aNeurobehavioral Comorbidities in Canine Idiopathic Epilepsy: New Insights into Cognitive and Emotional Domains
000161904 260__ $$c2025
000161904 5060_ $$aAccess copy available to the general public$$fUnrestricted
000161904 5203_ $$aNeurobehavioral comorbidities in dogs with idiopathic epilepsy (IE) are increasingly recognized, yet their phenotypic variability and clinical implications remain poorly understood. This study aimed to identify behavioral changes following seizure onset and to explore the feasibility of stratifying patients based on neurobehavioral profiles. Seventy client-owned dogs with IE were enrolled and grouped according to treatment: 29 had drug-resistant epilepsy (DRE), 29 were drug-sensitive (DSE), and 12 remained untreated. Owners completed a modified version of the C-BARQ questionnaire, assessing behaviors before and after seizure onset. Nearly one-third of behavioral items showed significant changes, particularly in attachment and attention-seeking behaviors, separation-related behaviors, eating behavior, and signs of cognitive decline such as reduced trainability and dementia-like signs. Principal component analysis followed by cluster analysis revealed two distinct neurobehavioral profiles: Cognitive and Emotional. The Cognitive cluster was associated with a higher total questionnaire score, poorer seizure control (predominantly DRE), and lower owner-perceived quality of life. In contrast, the Emotional cluster was more frequently observed in dogs with DSE or no treatment and was associated with higher quality of life scores. These findings support the clinical relevance of behavioral stratification in canine epilepsy and underscore the need for individualized, multimodal approaches to improve patient care.
000161904 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000161904 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000161904 700__ $$0(orcid)0000-0002-1581-3085$$aPalacio, Jorge$$uUniversidad de Zaragoza
000161904 700__ $$aMenchaca, Carolina
000161904 700__ $$0(orcid)0000-0001-5084-6555$$aGarcía Belenguer, Silvia$$uUniversidad de Zaragoza
000161904 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000161904 773__ $$g15, 11 (2025), 1592 [18 pp.]$$pAnimals (Basel)$$tAnimals$$x2076-2615
000161904 8564_ $$s907964$$uhttps://zaguan.unizar.es/record/161904/files/texto_completo.pdf$$yVersión publicada
000161904 8564_ $$s2812244$$uhttps://zaguan.unizar.es/record/161904/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000161904 909CO $$ooai:zaguan.unizar.es:161904$$particulos$$pdriver
000161904 951__ $$a2025-10-17-14:31:10
000161904 980__ $$aARTICLE