000161907 001__ 161907 000161907 005__ 20251017144639.0 000161907 0247_ $$2doi$$a10.1016/j.indcrop.2025.121335 000161907 0248_ $$2sideral$$a144477 000161907 037__ $$aART-2025-144477 000161907 041__ $$aeng 000161907 100__ $$aKulczynska, Julia 000161907 245__ $$aSustainable poly(vinyl alcohol)/chitosan electrospun nanofibers and casted films with bioactive additives – comparative study on physicochemical properties and in vitro biological activity 000161907 260__ $$c2025 000161907 5060_ $$aAccess copy available to the general public$$fUnrestricted 000161907 5203_ $$aChitosan is a biocompatible and biodegradable polysaccharide with a plethora of biomedical and food applications. Its functionalization with additional biopolymers and bioadditives allows to modify its antimicrobial, mechanical and tribological properties, as well as cell proliferation. Thus, the aim of this study was to investigate the physicochemical properties and in vitro biological activity of poly(vinyl alcohol)/chitosan electrospun nanofibers and casted films with an addition of Rosa damascena and Rosa rugosa extracts, as well as gold nanoparticles. Poly(vinyl alcohol)/chitosan nanofibers and films were both electrospun and dry-casted with morphology, wettability, mechanical, thermal, antimicrobial properties, as well as cytotoxicity being examined. Specific attention has been drawn to the methodological approach on nanofiber electrospinning. Results showed data variabilities in wettability, mechanical and thermal properties were a matter of material fabrication technique, while those of swelling ability and degradation related to material composition. Antimicrobial activity, as well as lack of significant cytotoxicity were observed for both poly(vinyl alcohol)/chitosan nanofibers and films with an addition of rose extracts, as well as gold nanoparticles. Results reported in this study suggested poly(vinyl alcohol)/chitosan nanofibers and films with the investigated additives as promising biocompatible biomaterials with potential applications suggested such as external drug delivery in wound healing, topical therapies, biodegradable packings. 000161907 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es 000161907 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000161907 700__ $$aChibrikov, Vadym 000161907 700__ $$aPawcenis, Dominika 000161907 700__ $$aJedrzejczyk, Roman J. 000161907 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, Victor$$uUniversidad de Zaragoza 000161907 700__ $$aCybulska, Justyna 000161907 700__ $$aZdunek, Artur 000161907 700__ $$aKyziol, Agnieszka 000161907 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química 000161907 773__ $$g233 (2025), 121335 [13 pp.]$$pInd. crops prod.$$tINDUSTRIAL CROPS AND PRODUCTS$$x0926-6690 000161907 8564_ $$s10813342$$uhttps://zaguan.unizar.es/record/161907/files/texto_completo.pdf$$yVersión publicada 000161907 8564_ $$s2261976$$uhttps://zaguan.unizar.es/record/161907/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000161907 909CO $$ooai:zaguan.unizar.es:161907$$particulos$$pdriver 000161907 951__ $$a2025-10-17-14:31:11 000161907 980__ $$aARTICLE