doi:10.1113/JP288757engSitko, SebastiánCastillo-García, AdriánValenzuela, Pedro L.Muscle memory theory: Implications for health, athletic performance and sports integrityART-2025-144531Introduction Maintaining optimal levels of skeletal muscle mass (and strength) is a cornerstone for both health and performance not only because of its widely known role in functions such as locomotion, but also as a result of less popular effects, such as its role in metabolism (Severinsen & Pedersen, 2020). For this reason, strategies aimed at enhancing or preserving skeletal muscle throughout its lifespan should be a priority, and efforts are needed to fully understand the physiological mechanisms involved in skeletal muscle mass regulation.2025http://zaguan.unizar.es/record/16190910.1113/JP288757http://zaguan.unizar.es/record/161909oai:zaguan.unizar.es:161909JOURNAL OF PHYSIOLOGY-LONDON (2025), [5 p.]byhttps://creativecommons.org/licenses/by/4.0/deed.esinfo:eu-repo/semantics/openAccess