000161911 001__ 161911
000161911 005__ 20251017144639.0
000161911 0247_ $$2doi$$a10.1111/obr.13941
000161911 0248_ $$2sideral$$a144534
000161911 037__ $$aART-2025-144534
000161911 041__ $$aeng
000161911 100__ $$aMasip, Guiomar$$uUniversidad de Zaragoza
000161911 245__ $$aPolygenic Risk and Nutrient Intake Interactions on Obesity Outcomes: A Systematic Review and Meta‐Analysis of Observational Studies
000161911 260__ $$c2025
000161911 5060_ $$aAccess copy available to the general public$$fUnrestricted
000161911 5203_ $$aBackground:
Diet is an important determinant of body weight and may modulate genetic susceptibility to obesity.ObjectiveThis systematic review and meta‐analysis aimed to synthesize evidence related to interactions between polygenic risk and nutrient intakes on obesity outcomes.
Methods:
MEDLINE, EMBASE, Web of Science, and Cochrane Library were systematically searched to identify observational studies that assessed interactions between polygenic risk and nutrient intakes on obesity‐related outcomes. Random effects meta‐analyses were performed for pooled polygenic risk score (PRS)–total fat intake and PRS–protein intake interaction coefficients on body mass index (BMI).
Results:
Twenty‐six publications were retrieved with studies conducted among European, Asian, and African samples. Dietary fats (saturated fat, omega‐3, and trans fat) and energy intake were most frequently reported to interact with PRS on obesity outcomes, but the total number of studies available was low. No significant interactions were identified in meta‐analyses of PRS interactions with total fat intake and protein intake on BMI. Several studies were rated as low quality, heterogeneity was high, and although study samples were racially diverse, PRSs tended to be based on samples of European ancestry.
Conclusion:
Evidence of interactions between polygenic risk and nutrient intakes on obesity outcomes is limited and inconsistent. Further research addressing limitations related to study quality and polygenic risk characterization is needed.
000161911 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es
000161911 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000161911 700__ $$aHan, Hannah Yang
000161911 700__ $$aMeng, Tongzhu
000161911 700__ $$aNielsen, Daiva E.
000161911 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000161911 773__ $$g(2025), e13941 [17 pp.]$$pObes. rev.$$tObesity Reviews$$x1467-7881
000161911 8564_ $$s3439886$$uhttps://zaguan.unizar.es/record/161911/files/texto_completo.pdf$$yVersión publicada
000161911 8564_ $$s2453805$$uhttps://zaguan.unizar.es/record/161911/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000161911 909CO $$ooai:zaguan.unizar.es:161911$$particulos$$pdriver
000161911 951__ $$a2025-10-17-14:31:12
000161911 980__ $$aARTICLE