000161968 001__ 161968
000161968 005__ 20251017144554.0
000161968 0247_ $$2doi$$a10.3390/jcm14124385
000161968 0248_ $$2sideral$$a144647
000161968 037__ $$aART-2025-144647
000161968 041__ $$aeng
000161968 100__ $$aAguinagalde, Borja
000161968 245__ $$aRecurrence Pattern of Left Upper Lobectomies and Trisegmentectomies: Systematic Review and Meta-Analysis
000161968 260__ $$c2025
000161968 5060_ $$aAccess copy available to the general public$$fUnrestricted
000161968 5203_ $$aBackground: Surgical resection remains the standard treatment for early-stage non-small-cell lung cancer (NSCLC). Traditionally, lobectomy has been considered the procedure of choice; however, emerging evidence suggests that trisegmentectomy may offer comparable outcomes. This meta-analysis evaluates whether left upper lobe trisegmentectomy provides non-inferior or superior oncologic outcomes compared to left upper lobectomy, with particular attention to recurrence patterns. Methods: Following PRISMA guidelines, we included comparative studies evaluating left upper lobectomy versus trisegmentectomy. Outcomes assessed included recurrence (locoregional and distant), morbidity, and the length of hospital stay. A meta-analysis was conducted using the metabin function from the R meta package. Results: Of 14 identified articles, 9 met the inclusion criteria. No significant differences were observed in locoregional recurrence. However, distant recurrence was significantly lower in the trisegmentectomy group (OR 0.58; 95% CI 0.41–0.82). While overall morbidity showed no significant difference (OR 0.95), analysis of matched studies favored trisegmentectomy (OR 0.73; 95% CI 0.56–0.96). Hospital stay was significantly shorter in the trisegmentectomy group (OR –0.94; 95% CI –1.26 to –0.63). Conclusions: Trisegmentectomy and lobectomy exhibit distinct recurrence patterns, with lobectomy associated with a higher rate of distant recurrence. Trisegmentectomy may provide oncologic and perioperative advantages in appropriately selected patients. The systematic review and meta-analysis are registered in PROSPERO (registration number: CRD420251066445).
000161968 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000161968 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000161968 700__ $$aFerrer-Bonsoms, Juan A.
000161968 700__ $$aLópez, Iker
000161968 700__ $$aLizarbe, Jon Ander
000161968 700__ $$aFernandez-Monge, Arantza
000161968 700__ $$aMainer, Maria
000161968 700__ $$0(orcid)0000-0003-0249-3104$$aEmbun, Raul$$uUniversidad de Zaragoza
000161968 700__ $$aZabaleta, Jon
000161968 7102_ $$11013$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Cirugía
000161968 773__ $$g14, 12 (2025), 4385 [12 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000161968 8564_ $$s2517014$$uhttps://zaguan.unizar.es/record/161968/files/texto_completo.pdf$$yVersión publicada
000161968 8564_ $$s2537258$$uhttps://zaguan.unizar.es/record/161968/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000161968 909CO $$ooai:zaguan.unizar.es:161968$$particulos$$pdriver
000161968 951__ $$a2025-10-17-14:12:45
000161968 980__ $$aARTICLE