161968 20251017144554.0 doi 10.3390/jcm14124385 sideral 144647 ART-2025-144647 eng Aguinagalde, Borja Recurrence Pattern of Left Upper Lobectomies and Trisegmentectomies: Systematic Review and Meta-Analysis 2025 Access copy available to the general public Unrestricted Background: Surgical resection remains the standard treatment for early-stage non-small-cell lung cancer (NSCLC). Traditionally, lobectomy has been considered the procedure of choice; however, emerging evidence suggests that trisegmentectomy may offer comparable outcomes. This meta-analysis evaluates whether left upper lobe trisegmentectomy provides non-inferior or superior oncologic outcomes compared to left upper lobectomy, with particular attention to recurrence patterns. Methods: Following PRISMA guidelines, we included comparative studies evaluating left upper lobectomy versus trisegmentectomy. Outcomes assessed included recurrence (locoregional and distant), morbidity, and the length of hospital stay. A meta-analysis was conducted using the metabin function from the R meta package. Results: Of 14 identified articles, 9 met the inclusion criteria. No significant differences were observed in locoregional recurrence. However, distant recurrence was significantly lower in the trisegmentectomy group (OR 0.58; 95% CI 0.41–0.82). While overall morbidity showed no significant difference (OR 0.95), analysis of matched studies favored trisegmentectomy (OR 0.73; 95% CI 0.56–0.96). Hospital stay was significantly shorter in the trisegmentectomy group (OR –0.94; 95% CI –1.26 to –0.63). Conclusions: Trisegmentectomy and lobectomy exhibit distinct recurrence patterns, with lobectomy associated with a higher rate of distant recurrence. Trisegmentectomy may provide oncologic and perioperative advantages in appropriately selected patients. The systematic review and meta-analysis are registered in PROSPERO (registration number: CRD420251066445). info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ferrer-Bonsoms, Juan A. López, Iker Lizarbe, Jon Ander Fernandez-Monge, Arantza Mainer, Maria Embun, Raul Universidad de Zaragoza (orcid)0000-0003-0249-3104 Zabaleta, Jon 1013 090 Universidad de Zaragoza Dpto. Cirugía Área Cirugía 14, 12 (2025), 4385 [12 pp.] J. clin.med. Journal of Clinical Medicine 2077-0383 2517014 http://zaguan.unizar.es/record/161968/files/texto_completo.pdf Versión publicada 2537258 http://zaguan.unizar.es/record/161968/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:161968 articulos driver 2025-10-17-14:12:45 ARTICLE