The DEPRE’5 study: pragmatic, multicentre, five-arm, parallel-group randomised controlled trial with blinded assessment to compare treatment strategies in major depression after a failed selective serotonin reuptake inhibitor treatment

Puigdemont, Dolors de Diego-Adeliño, Javier Elices, Matilde Leal, Itziar Cabello, Maria Rodriguez-Jimenez, Roberto Álvarez-Mon, Miguel Ángel García-Fernández, Lorena Aguilar García-Iturrospe, Eduardo José Escartí, Maria José Montejo, Angel Luis Montes, José Manuel Usall, Judith Gallego-Nogueras, Ascensión Lujan, Elena López-Carrilero, Raquel González-Pinto, Ana Ortiz-Jauregui, Agurtzane Blanch, Jordi Urretavizcaya, Mikel Colom, Francesc García-Campayo, Javier Ayuso-Mateos, José Luis Pérez, Víctor The DEPRE’5 study: pragmatic, multicentre, five-arm, parallel-group randomised controlled trial with blinded assessment to compare treatment strategies in major depression after a failed selective serotonin reuptake inhibitor treatment

Br. j. psychiatry

10.1192/bjp.2025.13 2025

2025