000161986 001__ 161986 000161986 005__ 20251017144610.0 000161986 0247_ $$2doi$$a10.3390/ijms26125850 000161986 0248_ $$2sideral$$a144610 000161986 037__ $$aART-2025-144610 000161986 041__ $$aeng 000161986 100__ $$aMosseri, Andrea 000161986 245__ $$aA Review of Silica-Based Nanoplatforms for Anticancer Cargo Delivery 000161986 260__ $$c2025 000161986 5060_ $$aAccess copy available to the general public$$fUnrestricted 000161986 5203_ $$aStimuli-responsive silica nanoparticles have emerged as a promising platform for the targeted and controlled delivery of therapeutic agents in cancer therapy. These nanoparticles possess unique physicochemical properties that allow for the stimuli-triggered release of loaded cargos, such as drugs, enzymes, oligonucleotides, photosensitizers, and metals. The stimuli-responsive nature of these nanoparticles enables them to respond to specific internal and external signals within the tumor microenvironment, including pH, temperature, and redox potential, among others. This leads to the enhanced targeting of cancer cells and improved therapeutic efficacy while minimizing the off-target effects. This review highlights recent advances in the development and application of stimuli-responsive silica nanoparticles for the delivery of multiple active agents for cancer therapy. Overall, stimuli-responsive silica nanoparticles offer great potential for the development of more effective cancer therapies with improved selectivity and reduced side effects. 000161986 536__ $$9info:eu-repo/grantAgreement/ES/MICIU/CEX2023-001286-S 000161986 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es 000161986 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000161986 700__ $$0(orcid)0000-0002-6399-0852$$aSanchez-Uriel, Leticia 000161986 700__ $$0(orcid)0000-0003-4874-6672$$aGarcia-Peiro, Jose I.$$uUniversidad de Zaragoza 000161986 700__ $$aHornos, Felipe 000161986 700__ $$0(orcid)0000-0002-4546-4111$$aHueso, Jose L.$$uUniversidad de Zaragoza 000161986 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química 000161986 7102_ $$15005$$2790$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Tecnologi. Medio Ambiente 000161986 773__ $$g26, 12 (2025), 5850 [34 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596 000161986 8564_ $$s3632592$$uhttps://zaguan.unizar.es/record/161986/files/texto_completo.pdf$$yVersión publicada 000161986 8564_ $$s2548727$$uhttps://zaguan.unizar.es/record/161986/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000161986 909CO $$ooai:zaguan.unizar.es:161986$$particulos$$pdriver 000161986 951__ $$a2025-10-17-14:16:52 000161986 980__ $$aARTICLE