162003 20251017144616.0 doi 10.3390/metabo15060368 sideral 144631 ART-2025-144631 eng Cádiz-Gallardo, María Pía Analysis of the Acute Cytokine Dynamics Induced in Professional Padel According to the Playing Side of the Court and Sex-Related Differences 2025 Access copy available to the general public Unrestricted Background/Objectives: Moderate-intensity physical exercise induces an anti-inflammatory state that may help prevent or manage various diseases. In contrast, high-intensity exercise is closely associated with systemic inflammation, which can lead to immunosuppression, especially when recovery periods are too short, reduced sports performance and potential health risks for the athlete. This study aimed to analyze the acute cytokine dynamics in professional padel players, focusing on differences related to the side of play on the court (forehand or backhand) and sex. Methods: A total of 21 elite padel players (11 females and 10 males; age: 27.7 ± 6.3 y) voluntarily participated in the study. Pro-inflammatory cytokines (interleukin (IL)-1ß, IL-2, IL-5, IL-6, IL-7, IL-8, IL-12, tumor necrosis factor alpha and interferon gamma) and anti-inflammatory cytokines (IL-5, IL-6, IL-10, IL-13) were analyzed before and after a padel match. Results: The results showed significant changes in pro- and anti-inflammatory, including a decrease in IL-7 (p = 0.02), an increase in IL-8 (p ≤ 0.001) and an increase in IL-10 (p = 0.001). No significant differences were observed based on the side of play on the court, suggesting that this variable does not influence the immune response. Conclusions: Competitive padel at an elite level elicits an anti-inflammatory response, characterized by an increase in IL-10 and a reduction in pro-inflammatory cytokines. This response highlights the potential health benefits of padel as a moderate-intensity sport, particularly in managing systemic inflammation. info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pradas, Francisco Universidad de Zaragoza (orcid)0000-0002-6829-0775 Patanè, Pamela García-Giménez, Alejandro Universidad de Zaragoza (orcid)0009-0002-1869-6854 Lecina, Miguel Universidad de Zaragoza (orcid)0000-0003-0454-6302 Carrasco, Luis 3001 187 Universidad de Zaragoza Dpto. Expres.Music.Plást.Corp. Área Didáctica Expres.Corporal 1006 245 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Educación Física y Depor. 15, 6 (2025), 368 [14 pp.] Metabolites 2218-1989 556519 http://zaguan.unizar.es/record/162003/files/texto_completo.pdf Versión publicada 2557131 http://zaguan.unizar.es/record/162003/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:162003 articulos driver 2025-10-17-14:19:45 ARTICLE