000162011 001__ 162011
000162011 005__ 20251017144618.0
000162011 0247_ $$2doi$$a10.1016/j.ijbiomac.2025.145441
000162011 0248_ $$2sideral$$a144600
000162011 037__ $$aART-2025-144600
000162011 041__ $$aeng
000162011 100__ $$aJimenez-Carretero, Monica
000162011 245__ $$aMagnetic hyperthermia drastically enhances killing of Mycobacterium tuberculosis by bacteriocin AS-48 grafted on biomimetic nanoparticles
000162011 260__ $$c2025
000162011 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162011 5203_ $$aMycobacterium tuberculosis, the etiological agent of human tuberculosis, is an intracellular pathogen responsible for one of the infectious diseases with highest mortality rates. Its ability to replicate inside alveolar macrophages and trigger the formation of granulomas, alongside the appearance of multidrug-resistant strains, impose the employment of drugs that exacerbate their toxic effects after the long therapies necessary to deal with the infection. As an alternative to conventional drugs, this work proposes the use of bacteriocin AS-48 immobilized on biomimetic magnetic nanoparticles (BMNPs) as a nanoformulation capable of killing M. tuberculosis in infected THP-1 macrophages, which allows combination with magnetic hyperthermia to increase its effectiveness. This work is a proof of concept of a nanosystem that could potentially be magnetically directed to infected areas, where it could be applied locally. Our results show that AS-48_BMNP nanoassemblies used against M. tuberculosis in vitro display a synergistic effect with magnetic hyperthermia that can completely eradicate the bacteria from infected macrophages in four days. This combined treatment represents a promising opportunity for the future development of a local therapy for the treatment of M. tuberculosis.
000162011 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-01658$$9info:eu-repo/grantAgreement/ES/MINECO/EQC2019-005930-P$$9info:eu-repo/grantAgreement/ES/MINECO/PDC2021-121135-I00
000162011 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es
000162011 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162011 700__ $$0(orcid)0000-0002-9713-2127$$aGómez, Ana Belén$$uUniversidad de Zaragoza
000162011 700__ $$aLázaro, Marina
000162011 700__ $$0(orcid)0000-0002-3027-2408$$aMillán-Placer, Ana Cristina
000162011 700__ $$aGaglio, Salvatore C.
000162011 700__ $$0(orcid)0000-0002-6649-9153$$aAnoz-Carbonell, Ernesto
000162011 700__ $$0(orcid)0000-0003-4409-1437$$aPicó, Ana$$uUniversidad de Zaragoza
000162011 700__ $$0(orcid)0000-0002-2174-6747$$aBaranyai, Zsuzsa
000162011 700__ $$aJabalera, Ylenia
000162011 700__ $$aMaqueda, Mercedes
000162011 700__ $$aCarrasco-Jiménez, María Paz
000162011 700__ $$aPerduca, Massimiliano
000162011 700__ $$0(orcid)0000-0003-1081-8482$$ade la Fuente, Jesús M.
000162011 700__ $$aIglesias, Guillermo R.
000162011 700__ $$aMontalbán-López, Manuel
000162011 700__ $$aJimenez-Lopez, Concepcion
000162011 700__ $$0(orcid)0000-0003-2076-844X$$aAínsa, José A.$$uUniversidad de Zaragoza
000162011 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000162011 7102_ $$11011$$2X$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cProy. investigación HQA
000162011 773__ $$g319, Part 2 (2025), 145441 [10 pp.]$$pInt. j. biol. macromol.$$tInternational journal of biological macromolecules$$x0141-8130
000162011 8564_ $$s2977015$$uhttps://zaguan.unizar.es/record/162011/files/texto_completo.pdf$$yVersión publicada
000162011 8564_ $$s2787766$$uhttps://zaguan.unizar.es/record/162011/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162011 909CO $$ooai:zaguan.unizar.es:162011$$particulos$$pdriver
000162011 951__ $$a2025-10-17-14:20:47
000162011 980__ $$aARTICLE