000162017 001__ 162017
000162017 005__ 20251017144619.0
000162017 0247_ $$2doi$$a10.1111/ijpo.70023
000162017 0248_ $$2sideral$$a144655
000162017 037__ $$aART-2025-144655
000162017 041__ $$aeng
000162017 100__ $$0(orcid)0000-0001-6899-5938$$aSeral-Cortes, Miguel$$uUniversidad de Zaragoza
000162017 245__ $$aMediterranean diet and obesity polygenic risk interaction on adiposity in European children: The <scp>IDEFICS</scp>/I.Family Study
000162017 260__ $$c2025
000162017 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162017 5203_ $$aTo examine whether changes in the Mediterranean Diet (MD) or any of its MD food groups modulate the genetic susceptibility to obesity in European youth, both in cross‐sectional and longitudinal analyses.MethodsFor cross‐sectional analysis, 1982 participants at baseline, 1649 in follow‐up 1 (FU1) and 1907 in follow‐up 2 (FU2), aged 2–16 years of the IDEFICS/I.Family studies were considered. For the longitudinal design, 1254 participants were included. Adherence to MD was assessed using the Mediterranean Diet Score (MDS), and genetic susceptibility to high BMI was assessed with a polygenic risk score (BMI‐PRS). Multiple linear regression models were fitted to estimate gene × MD effects on markers of obesity.ResultsIn cross‐sectional analyses, at baseline, higher MDS was associated with higher BMI in children with high genetic susceptibility (β = 0.12; 95% CI = [0.01, 0.24]). However, 6 years later, at FU2, higher MDS was associated with lower BMI (β = −0.19; 95% CI = [−0.38, −0.01]) in children with high genetic susceptibility, showing an attenuating MDS effect. Also in FU2, vegetables and legumes (V&L) showed inverse associations with BMI (β = −0.01; CI = [−0.02, −0.00]) and WC (β = −0.02; CI = [−0.03, −0.00]) regardless of the obesity genetic risk, although the effect sizes were small. In the longitudinal analyses, no MDS‐obesity associations or gene × diet interaction effects were observed.ConclusionsIn cross‐sectional analysis (baseline and FU2), the MD modulated the association between obesity susceptibility and adiposity indicators in European youth, having an exacerbating effect in children measured during infancy years and an attenuating effect in early adolescent years.
000162017 536__ $$9info:eu-repo/grantAgreement/EUR/FP6/FOOD-016181$$9info:eu-repo/grantAgreement/EC/FP7/266044/EU/Determinants of eating behaviour in European children, adolescents and their parents/I.FAMILY
000162017 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000162017 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162017 700__ $$aDrouard, Gabin
000162017 700__ $$aMasip, Guiomar$$uUniversidad de Zaragoza
000162017 700__ $$aBogl, Leonie H.
000162017 700__ $$aDe Henauw, Stefaan
000162017 700__ $$aForaita, Ronja
000162017 700__ $$aIntemann, Timm
000162017 700__ $$aLissner, Lauren
000162017 700__ $$aMolnar, Denes
000162017 700__ $$aNagrani, Rajini
000162017 700__ $$aPala, Valeria
000162017 700__ $$aPicó, Catalina
000162017 700__ $$aRusso, Paola
000162017 700__ $$aTognon, Gianluca
000162017 700__ $$aTornaritis, Michael
000162017 700__ $$aVeidebaum, Toomas
000162017 700__ $$aWright, Marvin N.
000162017 700__ $$0(orcid)0000-0001-6173-5850$$aMiguel-Etayo, Pilar de
000162017 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, Luis A.$$uUniversidad de Zaragoza
000162017 700__ $$aLabayen, Idoia
000162017 700__ $$a
000162017 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000162017 773__ $$g20, 8 (2025)$$pPediatr. obes.$$tPediatric obesity$$x2047-6302
000162017 8564_ $$s1743610$$uhttps://zaguan.unizar.es/record/162017/files/texto_completo.pdf$$yVersión publicada
000162017 8564_ $$s2021231$$uhttps://zaguan.unizar.es/record/162017/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162017 909CO $$ooai:zaguan.unizar.es:162017$$particulos$$pdriver
000162017 951__ $$a2025-10-17-14:20:49
000162017 980__ $$aARTICLE