000162054 001__ 162054
000162054 005__ 20251017144652.0
000162054 0247_ $$2doi$$a10.3389/fphys.2025.1498426
000162054 0248_ $$2sideral$$a144676
000162054 037__ $$aART-2025-144676
000162054 041__ $$aeng
000162054 100__ $$aAbdollahpur, Mostafa
000162054 245__ $$aTilt-induced changes in f-wave characteristics during atrial fibrillation: an experimental and computational investigation
000162054 260__ $$c2025
000162054 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162054 5203_ $$aIntroduction
This study explores transient and stationary effects of sympathetic and parasympathetic stimulation on f-wave characteristics in atrial fibrillation (AF) patients undergoing a tilt test. Transient phase is defined as the initial 2-minute interval following each postural change, reflecting immediate autonomic adaptation, whereas steady phase refers to the subsequent interval (from 3 minutes post-change until phase end) representing a stable autonomic state.
Methods
Our primary aim is to investigate how the two branches of the autonomic nervous system (ANS) influence the f-wave frequency time series (f(m)). An analysis of f(m) in terms of the mean over time (Ff) and the magnitude of respiration-modulated f(m) variations (ΔFf) is conducted during baseline supine rest (B), head-down tilt (HDT) and head-up tilt (HUT). We analyzed data from a previous study in which 24 patients with persistent AF underwent a tilt test protocol, during which electrocardiograms (ECGs) were recorded. A model-based method was used to extract f(m) series from the ECG. Subsequently, an orthogonal subspace projection method was employed to quantify ΔFf, considering an ECG-derived respiratory signal. Electrophysiological computational simulations were conducted on 2D and 3D human atrial persistent AF models to aid the interpretation of clinical findings. Various levels of cholinergic stimulation by acetylcholine and β-adrenergic stimulation by isoproterenol were tested in the models. The temporal modulation of acetylcholine, representing changes associated with respiration, was cyclically modeled using sinusoidal waveforms.
Results
Analysis of the clinical data showed a decrease in Ff from B to HDT and an increase from HDT to HUT. During HDT, ΔFf initially increased in the transient phase before decreasing in the steady phase, then rose again during HUT. Analysis of the simulated data showed that increasing the concentration of Isoproterenol and/or acetylcholine resulted in a rise in Ff. Additionally, the magnitude of ΔFf was shown to be associated with the extent of acetylcholine fluctuation.
Discussion
These results suggest that changes in f-wave frequency characteristics during HUT and HDT could be linked to changes in sympathetic activity, with parasympathetic activity possibly modulating the effects of sympathetic activity rather than being an independent driver of fibrillatory rate changes.
000162054 536__ $$9info:eu-repo/grantAgreement/ES/DGA/LMP141-21$$9info:eu-repo/grantAgreement/ES/DGA/LMP94_21$$9info:eu-repo/grantAgreement/EC/H2020/766082/EU/MultidisciplinarY training network for ATrial fibRillation monItoring, treAtment and progression/MY-ATRIA$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 766082-MY-ATRIA$$9info:eu-repo/grantAgreement/ES/MICINN/PID2022-140556OB-I00$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00
000162054 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000162054 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162054 700__ $$aCelotto, Chiara
000162054 700__ $$0(orcid)0000-0003-4273-5403$$aSánchez, Carlos$$uUniversidad de Zaragoza
000162054 700__ $$aPlappert, Félix
000162054 700__ $$aÖstenson, Sten
000162054 700__ $$aPlatonov, Pyotr G.
000162054 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, Pablo$$uUniversidad de Zaragoza
000162054 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, Esther$$uUniversidad de Zaragoza
000162054 700__ $$aSandberg, Frida
000162054 7102_ $$15007$$2520$$aUniversidad de Zaragoza$$bDpto. Informát.Ingenie.Sistms.$$cÁrea Ingen.Sistemas y Automát.
000162054 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000162054 773__ $$g16 (2025), 1498426 [15 pp.]$$pFront. physiol.$$tFrontiers in physiology$$x1664-042X
000162054 8564_ $$s472756$$uhttps://zaguan.unizar.es/record/162054/files/texto_completo.pdf$$yVersión publicada
000162054 8564_ $$s2544156$$uhttps://zaguan.unizar.es/record/162054/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162054 909CO $$ooai:zaguan.unizar.es:162054$$particulos$$pdriver
000162054 951__ $$a2025-10-17-14:36:43
000162054 980__ $$aARTICLE