000162116 001__ 162116
000162116 005__ 20251017144620.0
000162116 0247_ $$2doi$$a10.1021/jacs.5c07261
000162116 0248_ $$2sideral$$a144700
000162116 037__ $$aART-2025-144700
000162116 041__ $$aeng
000162116 100__ $$0(orcid)0000-0001-5835-1223$$aOrtega-Liebana, M. Carmen
000162116 245__ $$aNear-Infrared Light-Accelerated Bioorthogonal Drug Uncaging and Photothermal Ablation by Anisotropic Pd@Au Plasmonic Nanorods
000162116 260__ $$c2025
000162116 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162116 5203_ $$aSelective activation of chemotherapeutics at the tumor site via bioorthogonal catalysis is a promising strategy to reduce collateral damage to healthy tissues and organs. Despite significant advances in this field, targeted drug activation by transition-metal catalysts is still limited by insufficient spatiotemporal control over the metal-mediated uncaging process. Herein, we report the development of anisotropic Pd@Au plasmonic nanorods with the capacity to accelerate dealkylation reactions under near-infrared (NIR) irradiation, thereby enabling precise control over when and where these catalytic devices are switched on. We also show that the stability and in cellulo chemical properties of Pd@Au nanorods are enhanced by Au–S functionalization with PEGylated phospholipids and report the development of a novel masking group for prodyes and prodrugs: the POxOC group, designed to improve physicochemical properties and the rate of the Pd-triggered dye/drug release process. NIR-photoactivation of lipo-Pd@Au nanorods is able to catalyze the uncaging of inactive drug precursors and release heat to the environment, killing cancer cells in culture and xenografted in zebrafish. This work provides a novel targeted strategy for photothermal chemotherapy by NIR-laser focalization.
000162116 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2023-151080NB-I00$$9info:eu-repo/grantAgreement/ES/DGA/E13-23R$$9info:eu-repo/grantAgreement/EC/H2020/823717/EU/Enabling Science and Technology through European Electron Microscopy/ESTEEM3$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 823717-ESTEEM3$$9info:eu-repo/grantAgreement/ES/MICINN/PID2023-147912OA-I00$$9info:eu-repo/grantAgreement/ES/MICIU/CEX2023-001286-S
000162116 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000162116 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162116 700__ $$aTravnickova, Jana
000162116 700__ $$aAdam, Catherine
000162116 700__ $$aGonzález-Calderón, Davir
000162116 700__ $$aLorente-Macías, Álvaro
000162116 700__ $$aLochenie, Charles
000162116 700__ $$0(orcid)0000-0002-2071-9093$$aArenal, Raul
000162116 700__ $$aPatton, E. Elizabeth
000162116 700__ $$aUnciti-Broceta, Asier
000162116 773__ $$g147, 27 (2025), 23980-23990$$pJ. Am. Chem. Soc.$$tJournal of the American Chemical Society$$x0002-7863
000162116 8564_ $$s8104962$$uhttps://zaguan.unizar.es/record/162116/files/texto_completo.pdf$$yVersión publicada
000162116 8564_ $$s3183158$$uhttps://zaguan.unizar.es/record/162116/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162116 909CO $$ooai:zaguan.unizar.es:162116$$particulos$$pdriver
000162116 951__ $$a2025-10-17-14:21:28
000162116 980__ $$aARTICLE