162138 20251017144644.0 doi 10.1016/j.psychres.2025.116605 sideral 144722 ART-2025-144722 eng Roest, Annelieke M. Comorbidity and temporal associations between mental disorders among college students in the world mental health international college student initiative 2025 Access copy available to the general public Unrestricted Background. Mental disorders are highly prevalent among students worldwide. This study aims to examine comorbidity and temporal associations between mental disorders among students. Methods. The study included 72,288 students from 18 countries as part of the World Mental Health International College Student (WMH-ICS) Initiative, with cross-sectional data collected between 2017 and 2023. Screening for common DSM-5 disorders was conducted using validated screening measures. Latent variables were examined using exploratory principal axis factor analysis on a correlation matrix among the lifetime mental disorders. Based on age-of-onset information, multivariable poisson regression models were used to examine associations of prior disorders with the first onset of other disorders. Results. 27.0 % of students screened positive for only one lifetime disorder, 17.1 % for two, 10.9 % for three, and 10.6 % for 4+ disorders. In the factor analysis, three latent variables were found, comprising: internalizing disorders (generalized anxiety disorder, major depressive episode, post-traumatic stress disorder, and panic disorder), substance use disorders (drug use disorder and alcohol use disorder), and externalizing disorders (attention deficit/hyperactivity disorder and mania/hypomania). Prior internalizing and externalizing disorders were associated with the subsequent first onset of all other disorders with risk ratios ranging from 1.5–7.5. Substance use disorders were less consistently associated with the subsequent first onset of other disorders, but alcohol use disorder was associated with the first onset of drug use disorder and vice versa. Conclusions. Mental disorder comorbidity is common among students, and students with disorders across the internalizing and externalizing spectrum have an increased risk of future mental disorder comorbidities. info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion de Vries, Ymkje Anna Pozuelo, Julia R. Petukhova, Maria V. Lee, Sue Sampson, Nancy A Albor, Yesica Alhadi, Ahmad N. Alonso, Jordi Al-Saud, Nouf Altwaijri, Yasmin Andersson, Claes Atwoli, Lukoye Auerbach, Randy P. Muaka, Caroline Ayuya Báez-Mansur, Patricia M. Ballester, Laura Bantjes, Jason Baumeister, Harald Bendtsen, Marcus Benjet, Corina Berman, Anne H. Bruffaerts, Ronny Carrasco, Paula Chan, Silver C.N. Cohut, Irina Couder, María Anabell Covarrubias Díaz Crockett, Marcelo A. Cuijpers, Pim David, Oana A. Dong, Dong Ebert, David D. Gaete, Jorge Forero, Carlos García Gili, Margalida Gutiérrez-García, Raúl Haro, Josep Maria Hasking, Penelope Hunt, Xanthe Husky, Mathilde M. Jaguga, Florence Langer, Álvaro I. Léniz, Irene Liu, Yan Mac-Ginty, Scarlett Martínez, Vania McLafferty, Margaret Miranda, Andrea Monroy-Velasco, Iris Ruby Murray, Elaine K. Musyoka, Catherine M. Nedelcea, Catalin Núñez, Daniel O’Neill, Siobhan M. Piqueras, José A. Popescu, Codruta A. Prescivalli, Ana Paula Rapsey, Charlene Robinson, Kealagh Rodriguez-Jimenez, Tiscar Universidad de Zaragoza Saal, Wylene Siu, Oi-ling Stein, Dan J. Struijs, Sascha Y. Tomoiaga, Cristina T. Valdés-García, Karla Patricia Vargas-Contreras, Eunice Vigo, Daniel V. Wang, Angel Y. Wong, Samuel Y.S. Kessler, Ronald C. Boffo, Marilisa Borges, Guilherme Breet, Elsie Cristóbal-Narvaez, Paula Cruz-Hernández, Sergio Garnefski, Nadia Uribe, Praxedis Cristina Hernández Hurks, Petra Jacobs, Karen Jansen, Leontien Jiménez-Pérez, Ana Lucía Klinkenberg, Elisabeth F. Kraaij, Vivian Lima, Rodrigo Antunes Lochner, Christine Owuor, Francisca Ongecha Medina-Mora, Maria Elena Mori, Tiana Munro, Lonna Munthali, Richard J. Nooij, Jessica Paz-Peréz, Maria Abigail Rebagliato, Marisa Remmerswaal, Danielle Roca, Miquel Salemink, Elske van der Heijde, Claudia Voorspoels, Wouter Wiers, Reinout W. 4009 680 Universidad de Zaragoza Dpto. Psicología y Sociología Área Person.Eval.Trat.Psicoló. 351 (2025), 116605 [13 pp.] Psychiatry res. PSYCHIATRY RESEARCH 0165-1781 1464926 http://zaguan.unizar.es/record/162138/files/texto_completo.pdf Versión publicada 2365855 http://zaguan.unizar.es/record/162138/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:162138 articulos driver 2025-10-17-14:33:22 ARTICLE