000162140 001__ 162140 000162140 005__ 20251017144644.0 000162140 0247_ $$2doi$$a10.1007/s11606-025-09682-5 000162140 0248_ $$2sideral$$a144738 000162140 037__ $$aART-2025-144738 000162140 041__ $$aeng 000162140 100__ $$aGonzález-Pérez, Antonio 000162140 245__ $$aResponse to the Letter to the Editor: “Proton Pump Inhibitor Use and Worsening Kidney Function: A Retrospective Cohort Study Including 122,606 Acid-Suppressing Users” 000162140 260__ $$c2025 000162140 5203_ $$aWe thank Deng et al. for their comments on our study “Proton pump inhibitor use and worsening kidney function: a retrospective cohort study including 122,606 acid-suppressing users”. The authors suggested stratification by cumulative PPI dose or duration, as well as by the use of non-steroidal anti-inflammatory drugs or diuretics. We performed the suggested sub-analyses, and we did not find any noticeable differences. As an example, we show the sub-analysis stratified by NSAID use (Table 1). In addition, they recommended the inclusion of lifestyle and socioeconomic factors, which are not routinely collected in healthcare databases and are often difficult to standardize: Unfortunately, these variables are not included in the primary care database used for this study. In summary, after performing the analyses suggested by the authors, the conclusions of our study remain unchanged. 000162140 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000162140 655_4 $$ainfo:eu-repo/semantics/other$$vinfo:eu-repo/semantics/publishedVersion 000162140 700__ $$aMartínez-Domínguez, Samuel J.$$uUniversidad de Zaragoza 000162140 700__ $$aGarcía-Rodríguez, Luis A. 000162140 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000162140 773__ $$g(2025), [2 p.]$$pJ. gen. intern. med.$$tJOURNAL OF GENERAL INTERNAL MEDICINE$$x0884-8734 000162140 8564_ $$s549408$$uhttps://zaguan.unizar.es/record/162140/files/texto_completo.pdf$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2026-07-02 000162140 8564_ $$s1462603$$uhttps://zaguan.unizar.es/record/162140/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2026-07-02 000162140 909CO $$ooai:zaguan.unizar.es:162140$$particulos$$pdriver 000162140 951__ $$a2025-10-17-14:33:22 000162140 980__ $$aARTICLE