162211 20251017144612.0 doi 10.1002/adfm.202502999 sideral 144800 ART-2025-144800 eng Garcia-Peiro, Jose I. Universidad de Zaragoza (orcid)0000-0003-4874-6672 Evolving Platinum‐Copper Nanostructures for Enhanced Photothermal Therapy and Controlled Copper Release in Cancer Therapy 2025 Access copy available to the general public Unrestricted Nanotechnology provides a panoply of new tools in cancer therapy, enabling advanced treatments such as chemodyamic therapy (CDT), radiation therapy (RT), photothermal therapy (PTT) or photodynamic therapy (PDT). The therapeutic effect can be increased by combining one or more of these actions and this is usually considered already from the design of the nanoparticles (NPs). Bimetallic NPs are obvious candidates in this respect, being able to trigger a multifunctional response associated to each metal and achieving a synergistic action in combined therapies. In this work, we designed platinum‐copper bimetallic NPs (PtCu NPs) capable to evolve during treatment and fulfill a dual role as chemotherapeutic agents, (controlled release of ionic Cu), and as tumor ablation agents under near infrared (NIR) irradiation. Tuning the synthesis conditions demonstrated the influence of metal composition and alloying degree on the Cu release pattern when exposed to physiological media. The Cu ions released disrupt the redox balance in cells by generating reactive hydrogen species (likely hydroxyl radicals •OH through reaction with H2O2 overexpressed in the tumor microenvironment) while simultaneously oxidizing glutathione (GSH). After Cu release, the remaining Pt‐rich structures present enhanced photothermal (PT) response. The efficacy of the combined therapy enabled by these NPs has been evaluated in vitro and in vivo. info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Sancho-Albero, María Universidad de Zaragoza (orcid)0000-0001-8762-5457 Miguel, Silvia Mosseri, Andrea Hornos, Felipe Contreras-Montoya, Rafael Hueso, Jose L. Universidad de Zaragoza (orcid)0000-0002-4546-4111 Santamaria, Jesus Universidad de Zaragoza (orcid)0000-0002-8701-9745 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 5005 790 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Tecnologi. Medio Ambiente (2025), e02999 [15 PP.] Adv. funct. mater. Advanced Functional Materials 1616-301X 2996051 http://zaguan.unizar.es/record/162211/files/texto_completo.pdf Versión publicada 2615568 http://zaguan.unizar.es/record/162211/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:162211 articulos driver 2025-10-17-14:18:05 ARTICLE