000162244 001__ 162244
000162244 005__ 20251017144644.0
000162244 0247_ $$2doi$$a10.1016/j.prenap.2025.100304
000162244 0248_ $$2sideral$$a144793
000162244 037__ $$aART-2025-144793
000162244 041__ $$aeng
000162244 100__ $$aBotelho, Cláudia
000162244 245__ $$aCharacterizing the phenolic composition and exploring the antioxidant, anti-cancer, and anti-inflammatory potential of medicinal plant infusions
000162244 260__ $$c2025
000162244 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162244 5203_ $$aNatural products and their derivatives have played important roles in various fields, including nutrition, medicine and cosmetics. In this study, different formulated plant infusions, namely Purifying Body (PB), Boost Training (BT), Calm Night I Spirit (CN), and Boost Energy (BE) were analyzed regarding their phenolic composition and biological properties such as antioxidant, anti-inflammatory, and its influence on a different type of tumoral and non-tumoral cells. Nineteen phenolic compounds across six groups were identified, being cinnamic acid the most prevalent in all infusions. BE infusions exhibited the highest total phenolic content (5 g GAE/L), while BT had the lowest (2 g GAE/L). BE demonstrated superior antioxidant activity, correlating with its high phenolic content. The impact of plant infusions on cell metabolic activity revealing a concentration-dependent behaviour for three used cell lines [human embryonic kidney (HEK293t), normal mouse fibroblast (L929), and human colorectal adenocarcinoma (Caco-2)]. IC50 values indicated low toxicity on non-tumoral cells and higher inhibition on the metabolic activity of colon cancer Caco-2 cells. These effects can be due to the induction of cell cycle arrest and apoptosis. All plant infusions significantly prevented reactive oxygen species formation (oxidative stress regulation), and present anti-inflammatory capacity with a decrease of pro-inflammatory (IL-1β) and an increase of anti-inflammatory (IL-10) cytokines.
Overall, the formulated infusions have antioxidant and anti-inflammatory properties and a notable impact on colon cancer cells. This study revealed the potential of the tested infusions in various medical applications, such as preventive care, as well as in the nutraceutical field.
000162244 536__ $$9info:eu-repo/grantAgreement/ES/AEI/FJC2021-046978-I$$9info:eu-repo/grantAgreement/ES/DGA/B16-23R$$9info:eu-repo/grantAgreement/ES/ISCIII/CB06-03-1012
000162244 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000162244 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000162244 700__ $$aFerreira-Sousa, Diana
000162244 700__ $$aQuero, Javier
000162244 700__ $$aCosta-Barbosa, Augusto
000162244 700__ $$aTeixeira-Guedes, Catarina
000162244 700__ $$aSampaio, Paula
000162244 700__ $$0(orcid)0000-0002-3595-7668$$aRodríguez-Yoldi, María Jesús$$uUniversidad de Zaragoza
000162244 700__ $$aFerreira-Santos, Pedro
000162244 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000162244 773__ $$g8 (2025), 100304 [13 pp.]$$pPRENAP$$tPharmacological Research. Natural Products$$x2950-1997
000162244 8564_ $$s1059103$$uhttps://zaguan.unizar.es/record/162244/files/texto_completo.pdf$$yPostprint
000162244 8564_ $$s1117517$$uhttps://zaguan.unizar.es/record/162244/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000162244 909CO $$ooai:zaguan.unizar.es:162244$$particulos$$pdriver
000162244 951__ $$a2025-10-17-14:33:24
000162244 980__ $$aARTICLE