000162258 001__ 162258
000162258 005__ 20251017144552.0
000162258 0247_ $$2doi$$a10.1016/j.vetpar.2015.03.004
000162258 0248_ $$2sideral$$a116128
000162258 037__ $$aART-2015-116128
000162258 041__ $$aeng
000162258 100__ $$aEsteve, L.O.
000162258 245__ $$aHistopathological findings and detection of Toll-like receptor 2 in cutaneous lesions of canine leishmaniosis
000162258 260__ $$c2015
000162258 5203_ $$aA broad spectrum of clinical manifestations ranging from a chronic subclinical infection to a non-self-limiting illness has been described for canine leishmaniosis (CanL). This clinical variation is determined by a variable immune response, presumably genetically determined, against the infection. Although different types of adaptive immune response in dogs with CanL have been investigated in several studies, the mechanisms that underlie and determine this variability are still poorly understood. It is currently thought that innate immune response, and particularly the role of specific mediators of the innate immune system, such as toll-like receptors (TLRs), plays a central role in this polarization. However, there is limited data available concerning the role that TLRs play in canine Leishmania infantum infection.
The objective of this descriptive study was to characterize and compare the inflammatory pattern, the Leishmania burden and expression of TLR2 in skin lesions derived from dogs with different clinical stages of leishmaniosis and cutaneous lesions.
Routine histology, Leishmania and TLR2 immunohistochemistry assays were performed in 11 patients with papular dermatitis (stage I – mild disease) and 10 patients with other cutaneous lesions (stage II–III – moderate to severe disease).
A significantly higher frequency of granuloma formation was demonstrated in skin samples of dogs with stage I when compared with dogs of stage II–III. Although not statistically significant, a trend for a lower parasite burden was observed for skin lesions of dogs with stage I when compared with dogs of stage II–III. A lower expression of TLR2 in skin biopsies from dogs with stage I was statistically significant compared with stage II–III. The results obtained in this study indicated an association with TLR2 in the pathogenesis of canine cutaneous leishmaniosis. Further studies are required to fully elucidate these findings.
000162258 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000162258 590__ $$a2.242$$b2015
000162258 591__ $$aVETERINARY SCIENCES$$b10 / 136 = 0.074$$c2015$$dQ1$$eT1
000162258 591__ $$aPARASITOLOGY$$b13 / 36 = 0.361$$c2015$$dQ2$$eT2
000162258 592__ $$a1.21$$b2015
000162258 593__ $$aMedicine (miscellaneous)$$c2015$$dQ1
000162258 593__ $$aVeterinary (miscellaneous)$$c2015$$dQ1
000162258 593__ $$aParasitology$$c2015$$dQ2
000162258 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162258 700__ $$0(orcid)0000-0001-6209-4282$$aVillanueva-Saz, S.$$uUniversidad de Zaragoza
000162258 700__ $$aHosein, S.
000162258 700__ $$aSolano-Gallego, L.
000162258 7102_ $$11005$$2315$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Farmacología
000162258 773__ $$g209, 3-4 (2015), 157-163$$pVet. parasitol.$$tVETERINARY PARASITOLOGY$$x0304-4017
000162258 8564_ $$s3590056$$uhttps://zaguan.unizar.es/record/162258/files/texto_completo.pdf$$yVersión publicada
000162258 8564_ $$s1994182$$uhttps://zaguan.unizar.es/record/162258/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162258 909CO $$ooai:zaguan.unizar.es:162258$$particulos$$pdriver
000162258 951__ $$a2025-10-17-14:12:02
000162258 980__ $$aARTICLE