000162262 001__ 162262 000162262 005__ 20251017144557.0 000162262 0247_ $$2doi$$a10.1039/d5en00312a 000162262 0248_ $$2sideral$$a144944 000162262 037__ $$aART-2025-144944 000162262 041__ $$aeng 000162262 100__ $$aCazzagon, Virginia 000162262 245__ $$aThe SAbyNA platform: a guidance tool to support industry in the implementation of safe- and sustainable-by-design concepts for nanomaterials, processes and nano-enabled products 000162262 260__ $$c2025 000162262 5060_ $$aAccess copy available to the general public$$fUnrestricted 000162262 5203_ $$aSimple, cost-effective and reliable methods are needed for pragmatic, flexible, safe and sustainable evaluations at early stages of product (chemical/material) development. This is especially true for nanoforms and nano-enabled products, for which guidance on the application of validated methods and tools for the assessment and management of safety and sustainability is still lacking. The SAbyNA guidance platform fills these gaps in the following ways: by integrating i) informative modules covering the needs of all stakeholder profiles (i.e., industry, consultants, RTOs, and regulatory bodies) by guiding them in the choice of methods, models and tools for exposure and hazard assessment, as well as in the selection of specific safe-by-design interventions; and ii) assessment modules for a screening-level evaluation of environmental sustainability and costs and for a screening and detailed safety assessment of nanoforms and nano-enabled products along their life cycle. The potential of this digital tool to support different stakeholders towards safer and more sustainable developments is demonstrated in a real case study: a nano-enabled 3D-printed vacuum cleaner plastic component composed of single-walled carbon nanotube–polycarbonate composites with antistatic properties. This study shows how a user inputs data to perform a screening assessment on an additive manufacturing case study, and the digital platform provides the user with some safe-by-design recommendations, such as reducing the fiber length or rigidity or changing process parameters to reduce emissions. Hazard, exposure, costs, sustainability and functionality case study data were added in the detailed assessment module of the platform to check whether the implemented safe-by-design intervention was able to improve the safety profile of this nano-enabled product without affecting sustainability and functionality performances. This study also demonstrated the added value of using the SAbyNA guidance platform at the early stage of the nano-enabled product development for the quantification and visualization of safety, sustainability, cost and functionality aspects of nano-enabled products and processes. 000162262 536__ $$9info:eu-repo/grantAgreement/EC/H2020/862419/EU/Simple, robust and cost-effective approaches to guide industry in the development of safer nanomaterials and nano-enabled products/SAbyNA$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 862419-SAbyNA 000162262 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es 000162262 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000162262 700__ $$aVanhauten, Ralph 000162262 700__ $$aHanlon, James 000162262 700__ $$aJiménez, Araceli Sánchez 000162262 700__ $$aHarrison, Sam 000162262 700__ $$aAuffan, Melanie 000162262 700__ $$aBraakhuis, Hedwig 000162262 700__ $$aBoyles, Matthew 000162262 700__ $$aCandalija, Ana 000162262 700__ $$aKatsumiti, Alberto 000162262 700__ $$aRodriguez-Llopis, Isabel 000162262 700__ $$0(orcid)0000-0003-2936-242X$$aCatalan, Julia$$uUniversidad de Zaragoza 000162262 700__ $$aCross, Richard K. 000162262 700__ $$aLahive, Elma 000162262 700__ $$aMorel, Elise 000162262 700__ $$aSimeone, Felice C. 000162262 700__ $$aDelpivo, Camilla 000162262 700__ $$aClavaguera, Simon 000162262 700__ $$aSeddon, Richard 000162262 700__ $$aSalmatonidis, Apostolos 000162262 700__ $$aBarruetabeña, Leire 000162262 700__ $$aTraas, Lion 000162262 700__ $$aLotti, Davide 000162262 700__ $$aMays, Claire 000162262 700__ $$aVázquez-Campos, Socorro 000162262 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética 000162262 773__ $$pEnviron. sci. nano$$tEnvironmental science. Nano$$x2051-8153 000162262 8564_ $$s2958585$$uhttps://zaguan.unizar.es/record/162262/files/texto_completo.pdf$$yVersión publicada 000162262 8564_ $$s2690298$$uhttps://zaguan.unizar.es/record/162262/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000162262 909CO $$ooai:zaguan.unizar.es:162262$$particulos$$pdriver 000162262 951__ $$a2025-10-17-14:13:38 000162262 980__ $$aARTICLE