000162382 001__ 162382
000162382 005__ 20251017144654.0
000162382 0247_ $$2doi$$a10.1016/j.ncrna.2025.06.003
000162382 0248_ $$2sideral$$a144865
000162382 037__ $$aART-2025-144865
000162382 041__ $$aeng
000162382 100__ $$0(orcid)0000-0001-5612-0253$$aAparicio, Paula
000162382 245__ $$aSerum lncRNAs NEAT1, PVT1 and H19 as novel biomarkers for sarcopenia diagnosis and treatment response
000162382 260__ $$c2025
000162382 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162382 5203_ $$aSarcopenia, the loss of muscle mass and function generally associated to age, leads to increased dependence and mortality in older adults. Despite its clinical significance, unclear molecular mechanisms hinder the development of universal diagnostic and therapeutic monitoring methods. Recent research suggests long non-coding RNAs (lncRNAs) as potential biomarkers for muscle damage and sarcopenia. This study investigates the role of six specific lncRNAs as biomarkers for diagnosing and monitoring sarcopenia following physical training. For this purpose, an initial cohort of participants was divided into two experiments: Trial 1, a cross-sectional study comprising 54 sarcopenic patients and 29 robust controls, both including men and women; Trial 2, a non-randomized controlled trial, where the same sarcopenic patients from Trial 1 were divided in two groups: a Control Group (CG, n = 15); and a Trained Group (TG, n = 22). RNA was extracted from serum samples for all the participants, and the expression of 6 lncRNA (PVT1, HOTAIR, MALAT1, NEAT1, GAS5, H19), selected from the literature, was quantified by RT-PCR and compared between the different groups. Statistical evaluation uncovered four lncRNAs with significantly distinct expression in Trial 1: PVT1 (LOG2FC = 1.194), GAS5 (LOG2FC = 0.8224), NEAT1 (LOG2FC = 1.497) and H19 (LOG2FC = −0.9958) and three lncRNA significantly different between TG and CG in Trial 2 (PVT1 (LOG2FC = −1.796), MALAT1 (LOG2FC = 2.834) and H19 (LOG2FC = 1.355). Among them, NEAT 1 stands aout as promissing diagnostic marker ans PVT1 and H19 may serve as both diagnosis and treatment monitoring, altough further validation in larger cohorts is needed to confirm these results.
000162382 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2022-140911OB-I00$$9info:eu-repo/grantAgreement/ES/ISCIII/CB12-03-30038$$9info:eu-repo/grantAgreement/ES/ISCIII/CB18-05-0037$$9info:eu-repo/grantAgreement/ES/ISCIII/FEDER/PI21-00372$$9info:eu-repo/grantAgreement/ES/MICINN-AEI/PRTR-C17.I1$$9info:eu-repo/grantAgreement/ES/MINECO/DEP2016-78309-R$$9info:eu-repo/grantAgreement/ES/UZ/UZCUD2017-BIO-01$$9info:eu-repo/grantAgreement/ES/UZ/UZ2021-BIO-05
000162382 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000162382 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162382 700__ $$0(orcid)0000-0001-9802-8199$$aLópez-Royo, Tresa
000162382 700__ $$0(orcid)0000-0001-6523-5511$$aNavarrete-Villanueva, David$$uUniversidad de Zaragoza
000162382 700__ $$0(orcid)0000-0001-6492-2512$$aGómez Cabello, Alba María
000162382 700__ $$0(orcid)0000-0001-7757-3235$$aGonzález-Gross, Marcela
000162382 700__ $$0(orcid)0000-0002-2854-6684$$aAra, Ignacio
000162382 700__ $$0(orcid)0000-0002-4303-4097$$aVicente-Rodríguez, Germán$$uUniversidad de Zaragoza
000162382 700__ $$0(orcid)0000-0001-5687-6704$$aOsta, Rosario$$uUniversidad de Zaragoza
000162382 700__ $$0(orcid)0000-0002-7477-8742$$aManzano, Raquel$$uUniversidad de Zaragoza
000162382 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000162382 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000162382 7102_ $$11006$$2245$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Educación Física y Depor.
000162382 773__ $$g14 (2025), 166-176$$tNon-coding RNA Research$$x2468-0540
000162382 8564_ $$s3637962$$uhttps://zaguan.unizar.es/record/162382/files/texto_completo.pdf$$yVersión publicada
000162382 8564_ $$s2179331$$uhttps://zaguan.unizar.es/record/162382/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162382 909CO $$ooai:zaguan.unizar.es:162382$$particulos$$pdriver
000162382 951__ $$a2025-10-17-14:37:36
000162382 980__ $$aARTICLE