000162388 001__ 162388
000162388 005__ 20251017144655.0
000162388 0247_ $$2doi$$a10.1016/j.jinorgbio.2025.112987
000162388 0248_ $$2sideral$$a144841
000162388 037__ $$aART-2025-144841
000162388 041__ $$aeng
000162388 100__ $$aQuero, Javier
000162388 245__ $$aN-heterocyclic carbene gold(I) derivatives with long aliphatic side chains as potential anticancer agents in colon cancer
000162388 260__ $$c2025
000162388 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162388 5203_ $$aMild hyperthermia has emerged as a powerful tool in cancer therapy, prompting the development of materials that respond to heat with enhanced therapeutic action. Gold(I)-NHC complexes are emerging as promising anticancer agents due to their stability, tunability, and ability to inhibit sulfur- and selenium-dependent enzymes overexpressed in tumors. In this study, we synthesised carbene–gold(I) derivatives bearing fluorous and hydrocarbon chains to assess the role of polyfluorinated groups and the impact of mild hyperthermia (41 °C) on their cytotoxic activity. The compounds exhibited significant antiproliferative effects against Caco-2/TC7 colon carcinoma cells at both 37 °C and 41 °C. This activity may be associated with alterations in the levels of ROS (reactive oxygen species) within the cells and the activity of TrxR (thioredoxin reductase), resulting in modifications to the intracellular redox state and subsequent disruptions to the cell cycle. Under hyperthermic conditions, cytotoxicity was further enhanced via mitochondrial depolarization and activation of caspase-3-mediated apoptosis. Notably, fluorinated complexes displayed superior cytotoxicity compared to their alkylated analogues, highlighting the relevance of polyfluorinated chains in boosting therapeutic efficacy under heat-triggered conditions.
000162388 536__ $$9info:eu-repo/grantAgreement/ES/CIBERObn/CB06-03-1012$$9info:eu-repo/grantAgreement/ES/DGA/B16-23R$$9info:eu-repo/grantAgreement/ES/DGA/E07-23R$$9info:eu-repo/grantAgreement/ES/MICINN AEI/PID2022-136861NB-I00$$9info:eu-repo/grantAgreement/ES/MCINN/PID2022-136414OB-I00$$9info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG/NEWPOWER-S1-1.1-E01116
000162388 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000162388 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162388 700__ $$aAlconchel, Adrián
000162388 700__ $$aOrtega, Sara
000162388 700__ $$aBidooki, Seyed Hesamoddin$$uUniversidad de Zaragoza
000162388 700__ $$0(orcid)0000-0003-0553-0695$$aGimeno, Mª. Concepción
000162388 700__ $$0(orcid)0000-0002-3595-7668$$aRodriguez-Yoldi, Mª. Jesús$$uUniversidad de Zaragoza
000162388 700__ $$0(orcid)0000-0003-2457-3674$$aCerrada, Elena$$uUniversidad de Zaragoza
000162388 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000162388 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000162388 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000162388 773__ $$g272 (2025), 112987 [12 pp.]$$pJ. inorg. biochem.$$tJournal of Inorganic Biochemistry$$x0162-0134
000162388 8564_ $$s1311066$$uhttps://zaguan.unizar.es/record/162388/files/texto_completo.pdf$$yVersión publicada
000162388 8564_ $$s2571551$$uhttps://zaguan.unizar.es/record/162388/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162388 909CO $$ooai:zaguan.unizar.es:162388$$particulos$$pdriver
000162388 951__ $$a2025-10-17-14:38:06
000162388 980__ $$aARTICLE