000162405 001__ 162405
000162405 005__ 20251017144601.0
000162405 0247_ $$2doi$$a10.1002/1873-3468.70117
000162405 0248_ $$2sideral$$a144994
000162405 037__ $$aART-2025-144994
000162405 041__ $$aeng
000162405 100__ $$aDi Napoli, Giulia
000162405 245__ $$a<i>Mycobacterium tuberculosis</i> sulfurtransferase <scp>SseA</scp> is activated by its neighboring gene product Rv3284
000162405 260__ $$c2025
000162405 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162405 5203_ $$aTuberculosis remains a critical global health challenge, which underscores the need for new therapeutic targets. A potential drug target is the rhodanese‐like thiosulfate sulfurtransferase SseA, which plays a role in macrophage infection by Mycobacterium tuberculosis (Mtb) and its resistance to oxidative stress. In our research, we identified a protein (Rv3284), herein referred to as SufEMtb, that interacts with SseA and modulates its activity. Sequence analysis and molecular modeling revealed that SufEMtb enhances SseA enzymatic function by binding to its non‐catalytic N‐terminal domain and favoring an activating conformational change in a regulatory loop of SseA. This interaction appears crucial for effective enzyme activity and the maintenance of redox homeostasis in Mtb, making the SseA–SufEMtb complex a potential target for new therapies.
000162405 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/E35-23R$$9info:eu-repo/grantAgreement/ES/MICINN/PID2022-136369NB-I00
000162405 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000162405 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162405 700__ $$aFissore, Alex
000162405 700__ $$aSalladini, Edoardo
000162405 700__ $$aRaccuia, Eleonora
000162405 700__ $$aOliaro-Bosso, Simonetta
000162405 700__ $$aRuggiero, Alessia
000162405 700__ $$aBerisio, Rita
000162405 700__ $$0(orcid)0000-0001-8743-0182$$aMedina, Milagros$$uUniversidad de Zaragoza
000162405 700__ $$0(orcid)0000-0001-5702-4538$$aVelazquez-Campoy, Adrian$$uUniversidad de Zaragoza
000162405 700__ $$aAdinolfi, Salvatore
000162405 700__ $$aMarengo, Mauro
000162405 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000162405 773__ $$g(2025), [15 pp.]$$pFEBS lett.$$tFEBS Letters$$x0014-5793
000162405 8564_ $$s2576919$$uhttps://zaguan.unizar.es/record/162405/files/texto_completo.pdf$$yVersión publicada
000162405 8564_ $$s2341987$$uhttps://zaguan.unizar.es/record/162405/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162405 909CO $$ooai:zaguan.unizar.es:162405$$particulos$$pdriver
000162405 951__ $$a2025-10-17-14:14:12
000162405 980__ $$aARTICLE