000162425 001__ 162425
000162425 005__ 20251017144608.0
000162425 0247_ $$2doi$$a10.1017/S0033291725100974
000162425 0248_ $$2sideral$$a145039
000162425 037__ $$aART-2025-145039
000162425 041__ $$aeng
000162425 100__ $$aCostas-Carrera, Ana
000162425 245__ $$aObstetric complications, cortical gyrification, and cognition in first-episode psychosis
000162425 260__ $$c2025
000162425 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162425 5203_ $$aBackground: Obstetric complications (OCs) are associated with cognitive and brain abnormalities observed in patients with schizophrenia. Gyrification, a measure of cortical integrity sensitive to events occurring during the prenatal and perinatal periods, is also altered in first-episode psychosis (FEP). We examined the relationship between OCs and gyrification in FEP, as well as whether gyrification mediates the relationship between OCs and cognition.
Methods: We examined differences in the Local Gyrification Index (LGI) for the frontal, parietal, temporal, occipital, and cingulate cortices between 139 FEP patients and 125 healthy controls (HCs). Regression analyses explored whether OCs and diagnosis interact to explain LGI variation. Parametric mediation analyses were conducted to assess the effect of LGI on the relationship between OCs and cognition for FEP and HC.
Results: Significant LGI differences were observed between FEP patients and HC in the left parietal and bilateral cingulate and occipital cortices. There was a significant interaction between OCs and diagnosis on the left cingulate cortex (LCC) that was specific to males (p = 0.04) and was driven by gestational rather than intrauterine OCs. In HCs, OCs had a direct effect on working memory (WM) (p = 0.048) in the mediation analysis, whereas in FEP, we observed no significant effect of OCs on either verbal or WM.
Conclusions: OCs interact with diagnosis to predict LCC gyrification, such that males with FEP exposed to OCs exhibit the lowest LGI. OCs influence WM, and LCC gyrification may mediate this relation only in HC, suggesting a differential neurodevelopmental process in psychosis.
000162425 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-00661$$9info:eu-repo/grantAgreement/ES/ISCIII/PI24-00196$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/PI08-0208$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/PI11-00325$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/PI14-00612
000162425 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000162425 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162425 700__ $$aVerdolini, Norma
000162425 700__ $$aMezquida, Gisela
000162425 700__ $$aForte, Maria Florencia
000162425 700__ $$aJanssen, Joost
000162425 700__ $$aGarcia-Rizo, Clemente
000162425 700__ $$aMartinez-Aran, Anabel
000162425 700__ $$aAndres-Camazon, Pablo
000162425 700__ $$aSánchez-Torres, Ana Maria
000162425 700__ $$aBerge, Daniel
000162425 700__ $$ade la Serna, Elena
000162425 700__ $$aPenades, Rafael
000162425 700__ $$aValli, Isabel
000162425 700__ $$aAmoretti, Silvia
000162425 700__ $$a
000162425 773__ $$g55 (2025), [11 pp.]$$pPsychol. med.$$tPsychological Medicine$$x0033-2917
000162425 8564_ $$s702506$$uhttps://zaguan.unizar.es/record/162425/files/texto_completo.pdf$$yVersión publicada
000162425 8564_ $$s3364951$$uhttps://zaguan.unizar.es/record/162425/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162425 909CO $$ooai:zaguan.unizar.es:162425$$particulos$$pdriver
000162425 951__ $$a2025-10-17-14:16:07
000162425 980__ $$aARTICLE