npj digit. med. npj digit. med. Physics-informed machine learning digital twin for reconstructing prostate cancer tumor growth via PSA tests Camacho-Gomez Daniel Universidad de Zaragoza Borau Carlos Garcia-Aznar Jose Manuel Universidad de Zaragoza Gomez-Benito Maria Jose Universidad de Zaragoza Girolami Mark Perez Maria Angeles Universidad de Zaragoza 2025 research-article