000162438 001__ 162438
000162438 005__ 20251017144622.0
000162438 0247_ $$2doi$$a10.1007/s13105-025-01105-7
000162438 0248_ $$2sideral$$a145030
000162438 037__ $$aART-2025-145030
000162438 041__ $$aeng
000162438 100__ $$0(orcid)0000-0002-1033-6152$$aLorente-Cebrián, Silvia$$uUniversidad de Zaragoza
000162438 245__ $$aPhenolic compounds and epigenetic mechanisms regulating gene expression: effects on human health
000162438 260__ $$c2025
000162438 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162438 5203_ $$aAbstract
Phenolic compounds are a large class of phytochemicals with relevant physiological effects that are naturally found in plant-origin foods and derived products. Beneficial effects associated with polyphenol consumption are related to their ability to prevent and/or counteract disease features: they exert anti-inflammatory, antioxidant and anticancer effects, as well as protective actions against metabolic diseases. Phenolic compounds and their metabolites can modulate cell function by regulating gene expression. These effects are partially mediated through specific changes in epigenetic mechanisms such as DNA methylation, histone modifications and microRNA (miRNA) expression. Some polyphenols affect DNA methylation and are effective in counteracting deleterious actions induced by inflammatory/pro-oxidant factors, both in in vitro and in vivo settings. Specific mechanisms include modulation of methyl-transferases, whose levels are inhibited upon polyphenols treatment. Some polyphenols are histone deacetylase inhibitors, which prevent transcriptional repression and suppress tumor and inflammation genes by affecting selective regulation of miRNA expression. Their mostly recognized actions as anti-inflammatory and antioxidants seem to be partially mediated through regulation of individual miRNAs. Due to these actions, polyphenols and polyphenol-derived metabolites are under study in clinical and interventional trials for their benefits on inflammation and/or metabolic disorders. In conclusion, phenolic compounds might be an interesting approach to contribute to human homeostasis given their capacity to dynamically regulate epigenetic factors at cellular and systemic level. The present review aims to study available evidence regarding regulatory effects of polyphenols on gene expression, specifically mediated through epigenetic mechanisms.
000162438 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B03-23R$$9info:eu-repo/grantAgreement/ES/DGA/B44-23R$$9info:eu-repo/grantAgreement/ES/ISCIII/CB12-03-30002$$9info:eu-repo/grantAgreement/ES/MICINN-AEI/PID2022-141847OR-C33$$9info:eu-repo/grantAgreement/ES/MINECO/PID2022-141313OB-I00$$9info:eu-repo/grantAgreement/ES/MINECO/PID2022-141766OB-I00$$9info:eu-repo/grantAgreement/ES/MINECO/RTI2018-102205-B-I00
000162438 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000162438 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162438 700__ $$aCosta, André G. V.
000162438 700__ $$aCastillo-Rivas, J. Andrés
000162438 700__ $$0(orcid)0000-0001-8584-3979$$aCastro, Marta$$uUniversidad de Zaragoza
000162438 700__ $$0(orcid)0000-0002-8982-3737$$aArbonés-Mainar, José Miguel
000162438 700__ $$aGoñi, Saioa
000162438 700__ $$0(orcid)0000-0002-2147-9263$$aRemón, Sara$$uUniversidad de Zaragoza
000162438 700__ $$aAranaz, Paula
000162438 700__ $$0(orcid)0000-0001-6969-1055$$aLópez, Víctor
000162438 700__ $$0(orcid)0000-0001-6016-4726$$aMartín-Burriel, Inmaculada$$uUniversidad de Zaragoza
000162438 700__ $$aMilagro, Fermín I.
000162438 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000162438 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000162438 7102_ $$12008$$2780$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Tecnología de Alimentos
000162438 773__ $$g(2025), [18 pp.]$$pJ. physiol. biochem.$$tJournal of Physiology and Biochemistry$$x1138-7548
000162438 8564_ $$s2338624$$uhttps://zaguan.unizar.es/record/162438/files/texto_completo.pdf$$yVersión publicada
000162438 8564_ $$s2478926$$uhttps://zaguan.unizar.es/record/162438/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162438 909CO $$ooai:zaguan.unizar.es:162438$$particulos$$pdriver
000162438 951__ $$a2025-10-17-14:22:10
000162438 980__ $$aARTICLE