000162442 001__ 162442
000162442 005__ 20251017144630.0
000162442 0247_ $$2doi$$a10.3390/jimaging11070237
000162442 0248_ $$2sideral$$a145040
000162442 037__ $$aART-2025-145040
000162442 041__ $$aeng
000162442 100__ $$0(orcid)0000-0002-9068-7728$$aÁvila, Francisco J.$$uUniversidad de Zaragoza
000162442 245__ $$aVisual Neuroplasticity: Modulating Cortical Excitability with Flickering Light Stimulation
000162442 260__ $$c2025
000162442 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162442 5203_ $$aThe balance between cortical excitation and inhibition (E/I balance) in the cerebral cortex is critical for cognitive processing and neuroplasticity. Modulation of this balance has been linked to a wide range of neuropsychiatric and neurodegenerative disorders. The human visual system has well-differentiated magnocellular (M) and parvocellular (P) pathways, which provide a useful model to study cortical excitability using non-invasive visual flicker stimulation. We present an Arduino-driven non-image forming system to deliver controlled flickering light stimuli at different frequencies and wavelengths. By triggering the critical flicker fusion (CFF) frequency, we attempt to modulate the M-pathway activity and attenuate P-pathway responses, in parallel with induced optical scattering. EEG recordings were used to monitor cortical excitability and oscillatory dynamics during visual stimulation. Visual stimulation in the CFF, combined with induced optical scattering, selectively enhanced magnocellular activity and suppressed parvocellular input. EEG analysis showed a modulation of cortical oscillations, especially in the high frequency beta and gamma range. Our results support the hypothesis that visual flicker in the CFF, in addition to spatial degradation, initiates detectable neuroplasticity and regulates cortical excitation and inhibition. These findings suggest new avenues for therapeutic manipulation through visual pathways in diseases such as Alzheimer’s disease, epilepsy, severe depression, and schizophrenia.
000162442 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E44-23R
000162442 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000162442 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162442 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000162442 773__ $$g11, 7 (2025), 237 [18 pp.]$$tJOURNAL OF IMAGING$$x2313-433X
000162442 8564_ $$s2233923$$uhttps://zaguan.unizar.es/record/162442/files/texto_completo.pdf$$yVersión publicada
000162442 8564_ $$s2314431$$uhttps://zaguan.unizar.es/record/162442/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162442 909CO $$ooai:zaguan.unizar.es:162442$$particulos$$pdriver
000162442 951__ $$a2025-10-17-14:26:04
000162442 980__ $$aARTICLE