000162465 001__ 162465
000162465 005__ 20251017144651.0
000162465 0247_ $$2doi$$a10.1111/ijpo.70039
000162465 0248_ $$2sideral$$a145021
000162465 037__ $$aART-2025-145021
000162465 041__ $$aeng
000162465 100__ $$aNagore González, Carlos
000162465 245__ $$aMediating effect of infant rapid weight gain on the association between exclusive breastfeeding and the risk of obesity later in life
000162465 260__ $$c2025
000162465 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162465 5203_ $$aIntroduction
Obesity is a global health problem, with an impact on future health. Early factors such as infant feeding and rapid weight gain (RWG) may play a role in its development. However, their contribution is not fully understood.
Objective
To analyse associations and potential interactions between the type of infant feeding during the first 4 months of age, RWG and later development of obesity in children at 6 years of age.
Materials and Methods
This observational longitudinal study examines growth in 834 children born at term with adequate weight for their gestational age. Data were collected from birth to 6 years, focusing on weight, height and body mass index (BMI) z-scores. The relationships between infant feeding, RWG, and BMI at 6 years were explored using mediation models.
Results
Formula-fed infants showed higher BMI z-scores and obesity prevalence at 6 years compared to exclusively breastfed infants (p = 0.012 and p = 0.003 respectively). RWG also was associated with higher BMI z-scores and obesity (p < 0.001 in both cases), with formula-fed infants more likely to experience RWG (39.7% vs. 32.2%; p = 0.036). Mediation analysis revealed that the association between feeding type and BMI at 6 years is partly positively mediated by infant RWG up to 6 months.
Conclusions
Infant feeding practices, particularly exclusive breastfeeding in the first 4 months, are associated with weight and BMI trajectories up to 6 years. Rapid weight gain mediates this relationship in the first 6 months, but from 6 to 12 months.
000162465 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI13-02359
000162465 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000162465 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162465 700__ $$0(orcid)0000-0002-2219-3646$$aIglesia Altaba, Iris
000162465 700__ $$0(orcid)0009-0001-9733-698X$$aGuillén Sebastián, Cristina
000162465 700__ $$aÁlvarez Sauras, Maria Luisa
000162465 700__ $$aGarcía Enguita, Sheila
000162465 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, Luis A.$$uUniversidad de Zaragoza
000162465 700__ $$0(orcid)0000-0002-7985-9912$$aRodríguez, Gerardo$$uUniversidad de Zaragoza
000162465 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000162465 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000162465 773__ $$g(2025), e70039 [13 pp.]$$pPediatr. obes.$$tPediatric obesity$$x2047-6302
000162465 8564_ $$s1425728$$uhttps://zaguan.unizar.es/record/162465/files/texto_completo.pdf$$yVersión publicada
000162465 8564_ $$s2401735$$uhttps://zaguan.unizar.es/record/162465/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162465 909CO $$ooai:zaguan.unizar.es:162465$$particulos$$pdriver
000162465 951__ $$a2025-10-17-14:36:31
000162465 980__ $$aARTICLE