000162489 001__ 162489 000162489 005__ 20251017144601.0 000162489 0247_ $$2doi$$a10.1093/ejcts/ezt459 000162489 0248_ $$2sideral$$a85413 000162489 037__ $$aART-2014-85413 000162489 041__ $$aeng 000162489 100__ $$aRodríguez-Fuster, A. 000162489 245__ $$aMorbidity and mortality in a large series of surgical patients with pulmonary metastases of colorectal carcinoma: A prospective multicentre spanish study (GECMP-CCR-SEPAR) 000162489 260__ $$c2014 000162489 5060_ $$aAccess copy available to the general public$$fUnrestricted 000162489 5203_ $$aOBJECTIVE: Little information is available on postoperative morbidity and mortality after pulmonary metastasectomy. We describe the postoperative morbidity and mortality in a large multicentre series of patients after a first surgical procedure for pulmonary metastases of colorectal carcinoma (CRC) and identify the pre- and intraoperative variables influencing the clinical outcome. METHODS: A prospective, observational and multicentre study was conducted. Data were collected from March 2008 to February 2010. Patients were grouped into Groups A and B according to the presence or absence of postoperative complications. Variables in both groups were compared by univariate and multivariate analyses. P-values of <0.05 were considered statistically significant. RESULTS: A total of 532 patients (64.5% males) from 32 hospitals were included. The mean (SD) ages of both study groups were similar [68 (10) vs 67 (10) years, P = NS). A total of 1050 lung resections were performed (90% segmentectomies or wedge, n = 946 and 10% lobectomies or greater, n = 104). Group A included 83 (15.6%) patients who developed a total of 100 complications. These included persistent air leaks in 18, atelectasis in 13, pneumonia in 13, paralytic ileum in 12, arrhythmia in 9, acute respiratory distress syndrome in 4 and miscellanea in 31. Reoperation was performed in 5 (0.9%) patients due to persistent air leaks in 4 and lung ischaemia in 1. The mortality rate was 0.4% (n = 2). Causes of death were sepsis in 1 patient and ventricular fibrillation in 1. In the multivariate analysis, lobectomy or greater lung resection [odds ration (OR) 1.9, 95% confidence interval (95% CI) 1.04–3.3, P = 0.03], respiratory co-morbidity (OR 2.3, 95% CI 1.1–4.6, P = 0.01) and cardiovascular co-morbidity (OR 2, 95% CI 1–3.8, P = 0.02) were independent risk factors for postoperative morbidity. Videoassisted surgery vs thoracotomy showed a protective effect (OR 0.3, 95% CI 0.1–0.8, P = 0.01). CONCLUSIONS: The first episode of lung surgery for pulmonary metastases of CRC was associated with very low mortality and reoperation rates (<1%). The postoperative morbidity rate was 16%. Independent risk factors of postoperative morbidity were major lung resection and respiratory and/or cardiovascular co-morbidity. Video-assisted surgery showed a protective effect. 000162489 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000162489 590__ $$a3.304$$b2014 000162489 591__ $$aSURGERY$$b26 / 196 = 0.133$$c2014$$dQ1$$eT1 000162489 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b41 / 123 = 0.333$$c2014$$dQ2$$eT2 000162489 591__ $$aRESPIRATORY SYSTEM$$b16 / 57 = 0.281$$c2014$$dQ2$$eT1 000162489 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000162489 700__ $$aBelda-sanchis, J. 000162489 700__ $$aAguiló, R. 000162489 700__ $$0(orcid)0000-0003-0249-3104$$aEmbun, R. 000162489 700__ $$aMojal, S. 000162489 700__ $$aCall, S. 000162489 700__ $$aMolins, L. 000162489 700__ $$aDe andrés, J. J. R.$$uUniversidad de Zaragoza 000162489 700__ $$aon behalf of GECMP-CCR-SEPAR 000162489 7102_ $$11004$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Cirugía 000162489 773__ $$g45, 4 (2014), 671-676$$pEur. j. cardio-thorac. surg.$$tEUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY$$x1010-7940 000162489 8564_ $$s127972$$uhttps://zaguan.unizar.es/record/162489/files/texto_completo.pdf$$yVersión publicada 000162489 8564_ $$s2889479$$uhttps://zaguan.unizar.es/record/162489/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000162489 909CO $$ooai:zaguan.unizar.es:162489$$particulos$$pdriver 000162489 951__ $$a2025-10-17-14:14:14 000162489 980__ $$aARTICLE