000162490 001__ 162490
000162490 005__ 20251017144601.0
000162490 0247_ $$2doi$$a10.21037/tlcr-20-1055
000162490 0248_ $$2sideral$$a145073
000162490 037__ $$aART-2021-145073
000162490 041__ $$adeu
000162490 100__ $$aJarabo Sarceda, José Ramón
000162490 245__ $$aSpanish Lung Cancer Group SCAT trial: surgical audit to lymph node assessment based on IASLC recommendations
000162490 260__ $$c2021
000162490 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162490 5203_ $$aBackground: The Spanish Customized Adjuvant Therapy (SCAT) trial assessed the role of individualized adjuvant therapy in clinical N0 incidental pN1 and/or N2 non-small cell lung cancer (NSCLC) completely resected. We assessed surgical topics with an in-depth analysis of quality of lymphadenectomy based on International Association for the Study of Lung Cancer (IASLC) recommendations.
Methods: Patients with information about lymphadenectomy available were included (N=451). Prospectively collected data about tumor, type of resection, and postoperative morbidity and quality of lymph node dissection (LND) were retrospectively evaluated. Role of lymph node assessment on survival was analyzed using Kaplan-Meier curves, using regression models to identify prognostic factors.
Results: In 33.7%, 17.7% and 49.9% of cases, regions 7, 10 and 11 respectively were not assessed. In 21.1% of patients, less than three lymph node regions were biopsied, while in 19.6% of patients less than six lymph nodes were assessed. In 53,4% of patients only one N1 region was evaluated. From patients with positive N2, 8.9% had no N1 regions biopsied. Twenty-nine percent of patients with at least one N2 lymph node resected shown the highest region involved. Thirty-day postoperative mortality was unknown. Five-year overall survival (OS) was 61.7% (95% CI: 55.4–67.4%), 51.5% (95% CI: 39.2–62.4%) and 42.3% (95% CI: 32.1–52.2%) for patients with N1, N2 and N1+N2 disease, respectively (P<0.01). Both number of lymph nodes resected and number of lymph nodes involved by tumor were significantly related to prognosis.
Conclusions: IASLC recommendations for surgical resections were not followed in a high proportion of surgical procedures. Hilar and mediastinal lymph node assessment and involvement showed to impact prognosis. Surgical issues such as postoperative mortality could not be evaluated owing to trial design.
000162490 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000162490 590__ $$a4.726$$b2021
000162490 591__ $$aRESPIRATORY SYSTEM$$b24 / 66 = 0.364$$c2021$$dQ2$$eT2
000162490 591__ $$aONCOLOGY$$b105 / 245 = 0.429$$c2021$$dQ2$$eT2
000162490 592__ $$a1.067$$b2021
000162490 593__ $$aOncology$$c2021$$dQ2
000162490 594__ $$a4.8$$b2021
000162490 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162490 700__ $$aBolufer Nadal, Sergio
000162490 700__ $$aMongil Poce, Roberto
000162490 700__ $$aLópez de Castro, Pedro
000162490 700__ $$aMoreno Balsalobre, Ramón
000162490 700__ $$aPeñalver Cuesta, Juan Carlos
000162490 700__ $$0(orcid)0000-0003-0249-3104$$aEmbún Flor, Raul$$uUniversidad de Zaragoza
000162490 700__ $$aPac Ferrer, Joaquín
000162490 700__ $$aAlgar Algar, Francisco Javier
000162490 700__ $$aGámez García, Antonio Pablo
000162490 700__ $$aJiménez, Marcelo F.
000162490 700__ $$aSales-Badía, Jesús Gabriel
000162490 700__ $$aPereira, Eva
000162490 700__ $$aMassuti, Bartomeu
000162490 700__ $$aProvencio, Mariano
000162490 700__ $$aHernando Trancho, Florentino
000162490 7102_ $$11013$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Cirugía
000162490 773__ $$g10, 4 (2021), 1761-1772$$pTransl. lung cancer res.$$tTranslational lung cancer research$$x2218-6751
000162490 8564_ $$s568948$$uhttps://zaguan.unizar.es/record/162490/files/texto_completo.pdf$$yVersión publicada
000162490 8564_ $$s2561049$$uhttps://zaguan.unizar.es/record/162490/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162490 909CO $$ooai:zaguan.unizar.es:162490$$particulos$$pdriver
000162490 951__ $$a2025-10-17-14:14:15
000162490 980__ $$aARTICLE