000162504 001__ 162504
000162504 005__ 20251017144610.0
000162504 0247_ $$2doi$$a10.1093/annonc/mdw064
000162504 0248_ $$2sideral$$a145075
000162504 037__ $$aART-2016-145075
000162504 041__ $$aeng
000162504 100__ $$aHernández, J.
000162504 245__ $$aRole of major resection in pulmonary metastasectomy for colorectal cancer in the Spanish prospective multicenter study (GECMP-CCR)
000162504 260__ $$c2016
000162504 5203_ $$aBackground
Patients with pulmonary metastases from colorectal cancer (CRC) may benefit from aggressive surgical therapy. The objective of this study was to determine the role of major anatomic resection for pulmonary metastasectomy to improve survival when compared with limited pulmonary resection.
Patients and methods
Data of 522 patients (64.2% men, mean age 64.5 years) who underwent pulmonary resections with curative intent for CRC metastases over a 2-year period were reviewed. All patients were followed for a minimum of 3 years. Disease-specific survival (DSS) and disease-free survival (DFS) were assessed with the Kaplan–Meier method. Factors associated with DSS and DFS were analyzed using a Cox proportional hazards regression model.
Results
A total of 394 (75.6%) patients underwent wedge resection, 19 (3.6%) anatomic segmentectomy, 5 (0.9%) lesser resections not described, 100 (19.3%) lobectomy, and 4 (0.8%) pneumonectomy. Accordingly, 104 (19.9%) patients were treated with major anatomic resection and 418 (80.1%) with lesser resection. Operations were carried out with video-assisted thoracoscopic surgery (VATS) in 93 patients. The overall DSS and DFS were 55 and 28.3 months, respectively. Significant differences in DSS and DFS in favor of major resection versus lesser resection (DSS median not reached versus 52.2 months, P = 0.03; DFS median not reached versus 23.9 months, P < 0.001) were found. In the multivariate analysis, major resection appeared to be a protective factor in DSS [hazard ratio (HR) 0.6, 95% confidence interval (CI) 0.41–0.96, P = 0.031] and DFS (HR 0.5, 95% CI 0.36–0.75, P < 0.001). The surgical approach (VATS versus open surgical resection) had no effect on outcome.
Conclusion
Major anatomic resection with lymphadenectomy for pulmonary metastasectomy can be considered in selected CRC patient with sufficient functional reserve to improve the DSS and DFS. Further prospective randomized studies are needed to confirm the present results.
000162504 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000162504 590__ $$a11.855$$b2016
000162504 591__ $$aONCOLOGY$$b10 / 217 = 0.046$$c2016$$dQ1$$eT1
000162504 592__ $$a5.096$$b2016
000162504 593__ $$aHematology$$c2016$$dQ1
000162504 593__ $$aOncology$$c2016$$dQ1
000162504 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000162504 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162504 700__ $$aMolins, L.
000162504 700__ $$aFibla, J.J.
000162504 700__ $$aHeras, F.
000162504 700__ $$0(orcid)0000-0003-0249-3104$$aEmbún, R.$$uUniversidad de Zaragoza
000162504 700__ $$aRivas, J.J.
000162504 700__ $$aRivas, Juan J.$$uUniversidad de Zaragoza
000162504 700__ $$aMolins, Laureano
000162504 700__ $$aEmbún, Raúl
000162504 700__ $$aRivas, Francisco
000162504 700__ $$aHernández, Jorge
000162504 700__ $$aMier, José Manuel
000162504 700__ $$aHeras, Félix
000162504 700__ $$ade la Cruz, Javier
000162504 700__ $$aRubio, Matilde
000162504 700__ $$aFernández, Esther
000162504 700__ $$aCarbajo, Miguel
000162504 700__ $$aPeñalver, Rafael
000162504 700__ $$aJarabo, JoséRamón
000162504 700__ $$aGonzález-Rivas, Diego
000162504 700__ $$aBolufer, Sergio
000162504 700__ $$aPagás, Carlos
000162504 700__ $$aCall, Sergi
000162504 700__ $$aSmith, David
000162504 700__ $$aWins, Richard
000162504 700__ $$aArnau, Antonio
000162504 700__ $$aArroyo, Andrés
000162504 700__ $$aMarrón, M.Carmen
000162504 700__ $$aTamura, Akiko
000162504 700__ $$aBlanco, Montse
000162504 700__ $$ade Olaiz, Beatriz
000162504 700__ $$aMuñoz, Gemma
000162504 700__ $$aGarcía Prim, José M.
000162504 700__ $$aRombolá, Carlos
000162504 700__ $$aBarajas, Santiago García
000162504 700__ $$aRodríguez, Alberto
000162504 700__ $$aFreixinet, Jorge
000162504 700__ $$aRuiz, Javier
000162504 700__ $$aCarriquiry, Guillermo
000162504 700__ $$aRosenberg, Moisés
000162504 700__ $$aCanalís, Emilio
000162504 7102_ $$11004$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Cirugía
000162504 773__ $$g27, 5 (2016), 850-855$$pAnn. oncol.$$tANNALS OF ONCOLOGY$$x0923-7534
000162504 8564_ $$s208191$$uhttps://zaguan.unizar.es/record/162504/files/texto_completo.pdf$$yVersión publicada
000162504 8564_ $$s2644685$$uhttps://zaguan.unizar.es/record/162504/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162504 909CO $$ooai:zaguan.unizar.es:162504$$particulos$$pdriver
000162504 951__ $$a2025-10-17-14:17:09
000162504 980__ $$aARTICLE