000162583 001__ 162583
000162583 005__ 20260107185710.0
000162583 0247_ $$2doi$$a10.1016/j.arbres.2023.03.010
000162583 0248_ $$2sideral$$a145066
000162583 037__ $$aART-2023-145066
000162583 041__ $$aeng
000162583 100__ $$aRomero Román, Alejandra
000162583 245__ $$aPathological N1/N2 in Clinical Stage I Bronchogenic Carcinoma. Analysis From a Prospective Multicentre Database
000162583 260__ $$c2023
000162583 5203_ $$aObjectives: To determine the incidence of occult N1/N2 nodal metastases and associated risk factors in patients with non-small cell lung cancer no larger than 3 cm and deemed cN0 by CT and PET-CT in a prospective, multicentre national database.
Methods: Patients with a NSCLC no larger than 3 cm, deemed cN0 by PET-CT and CT scan, who had undergone at least a lobectomy, were selected from a national multicentre database of 3533 patients who had undergone anatomic lung resection between 2016 and 2018.
Clinical and pathological variables of patients with pN0 and patients with pN1/N2 were compared to identify factors associated with the presence of lymph node metastases. Chi2 and the Mann–Whitney U test were used for categorical and numerical variables, respectively. All variables with p < 0.2 in the univariate analysis were included in the multivariate logistic regression analysis.
Results: The study included 1205 patients from the cohort. The incidence of occult pN1/N2 disease was 10.70% (95%CI, 9.01–12.58).
The multivariable analysis revealed that the degree of differentiation, size, location (central or peripheral) and SUV of the tumour in PET, surgeon experience and number of lymph nodes resected were associated with occult N1/N2 metastases.
Conclusions: The incidence of occult N1/N2 in patients with bronchogenic carcinoma with cN0 tumours no larger than 3 cm is no negligible. Data about the degree of differentiation, tumour size in CT scan, maximal uptake of the tumour in PET-CT, location (central or peripheral), number of lymph nodes resected and surgeon seniority is relevant in order to detect patients at risk.
000162583 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000162583 590__ $$a8.7$$b2023
000162583 591__ $$aRESPIRATORY SYSTEM$$b9 / 101 = 0.089$$c2023$$dQ1$$eT1
000162583 592__ $$a0.464$$b2023
000162583 593__ $$aPulmonary and Respiratory Medicine$$c2023$$dQ3
000162583 594__ $$a3.5$$b2023
000162583 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162583 700__ $$aCrowley Carrasco, Silvana
000162583 700__ $$aGil Barturen, Mariana
000162583 700__ $$aRoyuela, Ana
000162583 700__ $$aObiols, Carme
000162583 700__ $$aCall, Sergi
000162583 700__ $$aRecuero, José Luis
000162583 700__ $$aRoyo, Íñigo
000162583 700__ $$0(orcid)0000-0003-0249-3104$$aEmbún, Raúl$$uUniversidad de Zaragoza
000162583 700__ $$aGómez de Antonio, David
000162583 7102_ $$11013$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Cirugía
000162583 773__ $$g59, 6 (2023), 364-369$$pArch. bronconeumol.$$tArchivos de Bronconeumologia$$x0300-2896
000162583 8564_ $$s335804$$uhttps://zaguan.unizar.es/record/162583/files/texto_completo.pdf$$yVersión publicada
000162583 8564_ $$s2463522$$uhttps://zaguan.unizar.es/record/162583/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162583 909CO $$ooai:zaguan.unizar.es:162583$$particulos$$pdriver
000162583 951__ $$a2026-01-07-18:55:45
000162583 980__ $$aARTICLE