000162616 001__ 162616 000162616 005__ 20251017144555.0 000162616 0247_ $$2doi$$a10.1016/j.anireprosci.2020.106599 000162616 0248_ $$2sideral$$a120570 000162616 037__ $$aART-2020-120570 000162616 041__ $$aeng 000162616 100__ $$0(orcid)0000-0001-9907-2941$$aMitjana, O.$$uUniversidad de Zaragoza 000162616 245__ $$aImmuno-castration of female and male pigs with anti-gonadotrophin releasing hormone vaccine: Morphometric, histopathological and functional studies of the reproductive system 000162616 260__ $$c2020 000162616 5060_ $$aAccess copy available to the general public$$fUnrestricted 000162616 5203_ $$aImmuno-castration is increasingly recommended in pigs due to welfare reasons; however, there are few studies in females compared to males. This aim of this study was to investigate the effects of immuno-castration in female and male pigs. The weight, the morphometric and microscopic characteristics of the reproductive organs, and the hormone concentrations were studied in 12 immunocastrated females (IF) and 12 immunocastrated males (IM) and compared with control animals (C). At slaughter, IF tended to have greater body weights than CF (P = 0.051), whereas in IM and CM pigs there were not body weight differences (P = 0.140). The weight of the reproductive tract and size of all individual organs were less in IF compared with CF. Results from histological assessments indicated IF had more atretic follicles and a thinner endometrial mucosa than control females. Hormone concentrations were not different between CF and IF (P > 0.050). As a result of immuno-castration, there was impaired spermatogenesis in most males. Results from microscopic evaluations indicated there was a marked decrease of spermatogonial cells and size of Leydig cells in the testicles. Accessory gland structures were affected in CM and IM with there being differences in gross and microscopic characteristics. Testosterone concentrations, unlike estradiol, were different in IM compared to CM (P < 0.001). These results provide evidence that immuno-castration with the anti-gonadotrophin releasing hormone vaccine is effective in female and male pigs and induces morphological and endocrine changes incompatible with fertility. 000162616 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 000162616 590__ $$a2.145$$b2020 000162616 591__ $$aAGRICULTURE, DAIRY & ANIMAL SCIENCE$$b23 / 63 = 0.365$$c2020$$dQ2$$eT2 000162616 591__ $$aVETERINARY SCIENCES$$b43 / 146 = 0.295$$c2020$$dQ2$$eT1 000162616 591__ $$aREPRODUCTIVE BIOLOGY$$b26 / 30 = 0.867$$c2020$$dQ4$$eT3 000162616 592__ $$a0.572$$b2020 000162616 593__ $$aAnimal Science and Zoology$$c2020$$dQ2 000162616 593__ $$aMedicine (miscellaneous)$$c2020$$dQ2 000162616 593__ $$aFood Animals$$c2020$$dQ2 000162616 593__ $$aEndocrinology$$c2020$$dQ2 000162616 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000162616 700__ $$0(orcid)0000-0001-6178-9891$$aBonastre, C.$$uUniversidad de Zaragoza 000162616 700__ $$0(orcid)0000-0001-5026-5144$$aTejedor, M.T.$$uUniversidad de Zaragoza 000162616 700__ $$0(orcid)0000-0001-7106-0068$$aGarza, L. 000162616 700__ $$0(orcid)0000-0002-3005-2675$$aLatorre, M.Á.$$uUniversidad de Zaragoza 000162616 700__ $$0(orcid)0000-0001-6629-6842$$aMoreno, B.$$uUniversidad de Zaragoza 000162616 700__ $$0(orcid)0000-0001-6964-7011$$aFalceto, M.V.$$uUniversidad de Zaragoza 000162616 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética 000162616 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal 000162616 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal 000162616 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal 000162616 773__ $$g221 (2020), [10 pp.]$$pAnim. reprod. sci.$$tAnimal Reproduction Science$$x0378-4320 000162616 8564_ $$s3128403$$uhttps://zaguan.unizar.es/record/162616/files/texto_completo.pdf$$yPostprint 000162616 8564_ $$s1078238$$uhttps://zaguan.unizar.es/record/162616/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000162616 909CO $$ooai:zaguan.unizar.es:162616$$particulos$$pdriver 000162616 951__ $$a2025-10-17-14:13:03 000162616 980__ $$aARTICLE