162616 20251017144555.0 doi 10.1016/j.anireprosci.2020.106599 sideral 120570 ART-2020-120570 eng Mitjana, O. Universidad de Zaragoza (orcid)0000-0001-9907-2941 Immuno-castration of female and male pigs with anti-gonadotrophin releasing hormone vaccine: Morphometric, histopathological and functional studies of the reproductive system 2020 Access copy available to the general public Unrestricted Immuno-castration is increasingly recommended in pigs due to welfare reasons; however, there are few studies in females compared to males. This aim of this study was to investigate the effects of immuno-castration in female and male pigs. The weight, the morphometric and microscopic characteristics of the reproductive organs, and the hormone concentrations were studied in 12 immunocastrated females (IF) and 12 immunocastrated males (IM) and compared with control animals (C). At slaughter, IF tended to have greater body weights than CF (P = 0.051), whereas in IM and CM pigs there were not body weight differences (P = 0.140). The weight of the reproductive tract and size of all individual organs were less in IF compared with CF. Results from histological assessments indicated IF had more atretic follicles and a thinner endometrial mucosa than control females. Hormone concentrations were not different between CF and IF (P > 0.050). As a result of immuno-castration, there was impaired spermatogenesis in most males. Results from microscopic evaluations indicated there was a marked decrease of spermatogonial cells and size of Leydig cells in the testicles. Accessory gland structures were affected in CM and IM with there being differences in gross and microscopic characteristics. Testosterone concentrations, unlike estradiol, were different in IM compared to CM (P < 0.001). These results provide evidence that immuno-castration with the anti-gonadotrophin releasing hormone vaccine is effective in female and male pigs and induces morphological and endocrine changes incompatible with fertility. info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 2.145 2020 AGRICULTURE, DAIRY & ANIMAL SCIENCE 23 / 63 = 0.365 2020 Q2 T2 VETERINARY SCIENCES 43 / 146 = 0.295 2020 Q2 T1 REPRODUCTIVE BIOLOGY 26 / 30 = 0.867 2020 Q4 T3 0.572 2020 Animal Science and Zoology 2020 Q2 Medicine (miscellaneous) 2020 Q2 Food Animals 2020 Q2 Endocrinology 2020 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Bonastre, C. Universidad de Zaragoza (orcid)0000-0001-6178-9891 Tejedor, M.T. Universidad de Zaragoza (orcid)0000-0001-5026-5144 Garza, L. (orcid)0000-0001-7106-0068 Latorre, M.Á. Universidad de Zaragoza (orcid)0000-0002-3005-2675 Moreno, B. Universidad de Zaragoza (orcid)0000-0001-6629-6842 Falceto, M.V. Universidad de Zaragoza (orcid)0000-0001-6964-7011 1001 420 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Genética 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 2008 700 Universidad de Zaragoza Dpto. Produc.Animal Cienc.Ali. Área Producción Animal 1009 617 Universidad de Zaragoza Dpto. Patología Animal Área Medicina y Cirugía Animal 221 (2020), [10 pp.] Anim. reprod. sci. Animal Reproduction Science 0378-4320 3128403 http://zaguan.unizar.es/record/162616/files/texto_completo.pdf Postprint 1078238 http://zaguan.unizar.es/record/162616/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:162616 articulos driver 2025-10-17-14:13:03 ARTICLE