000162693 001__ 162693
000162693 005__ 20251017144559.0
000162693 0247_ $$2doi$$a10.1016/j.patol.2025.100838
000162693 0248_ $$2sideral$$a145284
000162693 037__ $$aART-2025-145284
000162693 041__ $$aeng
000162693 100__ $$aGarcía-Fuertes, Sonia
000162693 245__ $$aGranular cell tumour of the breast: An uncommon benign lesion with suspicious radiological features. Case report and literature review
000162693 260__ $$c2025
000162693 5203_ $$aGranular cell tumour is an uncommon benign lesion of neural lineage, associated with ATP6AP1 and ATP6AP2 inactivating mutations (endosomal pH regulators). These tumours typically develop in the head and neck region, particularly in the tongue, and are rarely found in the mammary gland, with an estimated incidence of 1:1000 of all breast tumours. They have similar clinical and radiological features, that usually mimic malignant lesions with spiculated margins. Histologically, they present a characteristic morphology, which may require differential diagnosis from other granular cell entities, including benign conditions (such as histiocyte-rich inflammatory reactions) and malignant neoplasms such as the histiocytoid variant of lobular carcinoma or apocrine carcinoma. We present a case of granular cell tumour of the breast, radiologically classified as BI-RADS 5, to highlight the importance of morphological and immunohistochemical studies for establishing a definitive diagnosis.
000162693 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000162693 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162693 700__ $$aFranco-Rubio, José Ignacio$$uUniversidad de Zaragoza
000162693 7102_ $$11013$$2020$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Anatomía Patológica
000162693 773__ $$g58, 4 (2025), 100838 [5 pp.]$$pRev. esp. patol.$$tRevista Española de Patologia$$x1699-8855
000162693 8564_ $$s2043169$$uhttps://zaguan.unizar.es/record/162693/files/texto_completo.pdf$$yVersión publicada
000162693 8564_ $$s1989922$$uhttps://zaguan.unizar.es/record/162693/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162693 909CO $$ooai:zaguan.unizar.es:162693$$particulos$$pdriver
000162693 951__ $$a2025-10-17-14:13:55
000162693 980__ $$aARTICLE