000162706 001__ 162706
000162706 005__ 20251017144602.0
000162706 0247_ $$2doi$$a10.1016/j.ajpc.2025.101072
000162706 0248_ $$2sideral$$a145275
000162706 037__ $$aART-2025-145275
000162706 041__ $$aeng
000162706 100__ $$aMérida, Diana María
000162706 245__ $$aPhthalate exposure is associated with subclinical coronary atherosclerosis: The Aragon Workers' Health Study (AWHS)
000162706 260__ $$c2025
000162706 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162706 5203_ $$aBackground and objectives: Phthalates are implicated in mechanisms underlying the development of cardiovascular disease, such as oxidative stress, lipid peroxidation, endothelial dysfunction, and activation of procoagulant pathways. This study aimed to evaluate the association between phthalate exposure and subclinical coronary atherosclerosis (SCA).
Methods: A total of 1119 Spanish male workers from a car assembly plant (mean age: 50.9 years) were included. Urinary metabolites of 11 phthalates and ΣDEHP were analyzed. SCA was defined as coronary artery calcium ≥ 100 Agatston units. Logistic regression models were used to estimate the association between phthalates (natural log-transformed) and SCA, adjusting for sociodemographic, lifestyle, and cardiovascular risk factors. Dose-response relationships were explored using restricted cubic splines.
Results: The prevalence of SCA was 10.2 %. Participants with SCA had a median Mono-ethyl phthalate (MEP) concentration of 126.1 µg/g-creatinine compared to 99.3 µg/g-creatinine in those without SCA. A 1-unit increase in the natural logarithm of MEP was associated with a 21 % higher prevalence of SCA (OR: 1.21; 95 % CI: 1.02–1.44), showing a linear relationship. Positive but non-significant associations were observed for MiBP and MnBP. Sensitivity analyses with phthalates in original units (ng/ml) and adjustments for urinary creatinine showed consistent results.
Conclusions: Exposure to MEP is associated with an increased prevalence of SCA in male workers, suggesting that the exposure to this phthalate may play a role in the early stages of cardiovascular disease. These findings provide a basis for public health initiatives aimed at reducing phthalate exposure for the primary prevention of cardiovascular disease.
000162706 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-144$$9info:eu-repo/grantAgreement/ES/ISCIII/PI23-240
000162706 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000162706 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162706 700__ $$aTorrijo-Belanche, Carolina$$uUniversidad de Zaragoza
000162706 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, Belén$$uUniversidad de Zaragoza
000162706 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, Martín$$uUniversidad de Zaragoza
000162706 700__ $$aRey-García, Jimena
000162706 700__ $$aGimeno-Ruiz, Sofía
000162706 700__ $$aBayán-Bravo, Ana
000162706 700__ $$aGuallar-Castillón, Pilar
000162706 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000162706 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000162706 773__ $$g23 (2025), 101072 [10 pp.]$$tAmerican journal of preventive cardiology$$x2666-6677
000162706 8564_ $$s1397564$$uhttps://zaguan.unizar.es/record/162706/files/texto_completo.pdf$$yVersión publicada
000162706 8564_ $$s2054884$$uhttps://zaguan.unizar.es/record/162706/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162706 909CO $$ooai:zaguan.unizar.es:162706$$particulos$$pdriver
000162706 951__ $$a2025-10-17-14:14:23
000162706 980__ $$aARTICLE