162716 20251017144602.0 doi 10.3389/fphar.2025.1530139 sideral 145369 ART-2025-145369 deu Bengoa-Urrengoechea, Irantzu Factors associated with prescription of modern antidiabetics in newly diagnosed patients with type 2 diabetes. a real-world data study in a Spanish region 2025 Access copy available to the general public Unrestricted AimTo describe the patterns of first prescription of antidiabetic drugs (AD) in patients with type 2 diabetes (T2D) and analyze the factors associated with the prescription of a modern one.MethodsObservational longitudinal study conducted in the CArdiovascular Risk factors for HEalth Services research (CARhES) cohort. Individuals older than 15, resident in Aragón (Spain), diagnosed with T2D during 2018–2022 were selected and followed-up until 31st December 2022. Secondary use of data from the health system provided sociodemographic, clinical and pharmacological prescription information. We also considered additional variables by Basic Healthcare Area (BHA) of residence. AD were classified into “classical” and “modern” and their differences were described and compared. A multilevel methodology stratified by sex was developed, considering individual characteristics and characteristics of the BHA of residence, to analyze the factors associated to a modern AD.ResultsOur population-based cohort of 22,892 patients were mostly male, native, low-income and living in non-depopulated BHA. People who were younger, with heart failure, ischemic heart disease, chronic renal failure, obesity, with a previous major adverse cardiovascular event, higher socioeconomic level or lived in less deprived and more depopulated areas were more likely to get a modern AD prescription.ConclusionOur analyses showed that prescribing practices vary according to a range of sociodemographic, clinical and geographical characteristics. Knowledge of these factors is essential for implementing and improving equitable and person-centered approaches. info:eu-repo/grantAgreement/ES/DGA-GRISSA/B09-23R info:eu-repo/grantAgreement/ES/ISCIII/PI22-01193 info:eu-repo/grantAgreement/ES/ISCIII-RICAPPS/RD21-0016-0005 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Aguilar-Palacio, Isabel Universidad de Zaragoza (orcid)0000-0001-7293-701X Rabanaque, María José Universidad de Zaragoza (orcid)0000-0002-6671-5661 Lallana, María Jesús Gamba Cabezas, Adriana Malo, Sara Universidad de Zaragoza (orcid)0000-0002-7194-8275 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 16 (2025), [11 pp.] Front. pharmacol. Frontiers in Pharmacology 1663-9812 1032687 http://zaguan.unizar.es/record/162716/files/texto_completo.pdf Versión publicada 2043204 http://zaguan.unizar.es/record/162716/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:162716 articulos driver 2025-10-17-14:14:24 ARTICLE