000162721 001__ 162721
000162721 005__ 20251017144603.0
000162721 0247_ $$2doi$$a10.1016/j.cdnut.2025.107511
000162721 0248_ $$2sideral$$a145251
000162721 037__ $$aART-2025-145251
000162721 041__ $$aeng
000162721 100__ $$0(orcid)0000-0002-1655-568X$$aBenedicto-Toboso, Mª Isabel$$uUniversidad de Zaragoza
000162721 245__ $$aEffect of Dietary Fiber Intake on Chronic Low-Grade Inflammation in Children and Adolescents: A Systematic Review and Meta-analysis of Randomized Controlled Trials
000162721 260__ $$c2025
000162721 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162721 5203_ $$aPrevious research suggests that dietary fiber (DF) intake may help reduce chronic low-grade inflammation (CLGI), a condition linked to the early development of cardiometabolic risk factors. Childhood and adolescence represent critical periods for preventing noncommunicable diseases, when adopting healthy eating habits, including adequate fiber consumption, could effectively control CLGI. However, the evidence on DF’s impact on CLGI in the pediatric population remains inconsistent and has not been comprehensively reviewed in a single article. Therefore, we aimed to conduct a systematic review and meta-analysis to assess the effect of DF intake on CLGI in children and adolescents. A systematic search was performed in 4 databases up to January 2025. Two reviewers screened 2030 studies based on inclusion criteria: randomized controlled trials involving participants ≤18 y, interventions (Is) with any type of DF (supplementation, fiber-rich foods, or fiber intake advice) and reporting serum CLGI markers, including C-reactive protein (CRP), interleukin (IL)-6 and TNF-α, among others. Twenty-five randomized controlled trials were included in the systematic review, which showed that DF may have beneficial effects on CRP, IL-10, adiponectin, IL-1β, and IL-6 concentrations; though findings were inconsistent, with some studies reporting no significant changes. Meta-analysis was conducted for CRP, IL-6, and TNF-α. Meta-analysis for CRP concentrations included 10 studies and revealed a significant decrease following DF Is compared to controls (mean difference: –0.640; 95% CI: –1.075, –0.204). Meta-regression revealed that Is based on fiber supplementation resulted in significantly greater CRP reductions compared to those involving fiber-rich foods. Meta-analysis for IL-6 and TNF-α concentrations showed no significant effect after DF I. In conclusion, this review provides evidence that fiber Is may have a beneficial impact on certain markers of CLGI in children and adolescents, particularly by reducing serum CRP concentrations. However, the findings also reveal inconsistencies in the effects of fiber intake on other inflammatory markers.
000162721 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000162721 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162721 700__ $$aFreire Salviano, Andressa
000162721 700__ $$aMiguel-Berges, María L
000162721 700__ $$aRueda-De Torre, Isabel$$uUniversidad de Zaragoza
000162721 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, Luis A$$uUniversidad de Zaragoza
000162721 700__ $$0(orcid)0000-0002-0303-7912$$aSantaliestra-Pasías, Alba M$$uUniversidad de Zaragoza
000162721 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000162721 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000162721 773__ $$g9, 9 (2025), 107511 [20 pp.]$$tCurrent Developments in Nutrition$$x2475-2991
000162721 8564_ $$s2863090$$uhttps://zaguan.unizar.es/record/162721/files/texto_completo.pdf$$yVersión publicada
000162721 8564_ $$s2562002$$uhttps://zaguan.unizar.es/record/162721/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162721 909CO $$ooai:zaguan.unizar.es:162721$$particulos$$pdriver
000162721 951__ $$a2025-10-17-14:14:31
000162721 980__ $$aARTICLE