000162722 001__ 162722
000162722 005__ 20251017144603.0
000162722 0247_ $$2doi$$a10.3390/life15071147
000162722 0248_ $$2sideral$$a145252
000162722 037__ $$aART-2025-145252
000162722 041__ $$aeng
000162722 100__ $$aRico-González, Markel
000162722 245__ $$aExercise as Modulator of Brain-Derived Neurotrophic Factor (BDNF) in Children: A Systematic Review of Randomized Controlled Trials
000162722 260__ $$c2025
000162722 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162722 5203_ $$aBackground: Brain-derived neurotrophic factor (BDNF) plays a pivotal role in neuroplasticity and cognitive development. While exercise has been shown to modulate BDNF levels in adults, evidence in children remains limited and heterogeneous. Methods: A systematic review was conducted following PRISMA guidelines to examine randomized controlled trials investigating exercise effects on BDNF in children aged 5–12 years. The databases searched included FECYT, PubMed, SPORTDiscus, ProQuest Central, SCOPUS, and Cochrane Library through June 2025. Study quality was assessed using the PEDro scale. Results: Five randomized controlled trials (N = 385 participants) met inclusion criteria. Two studies (40%) demonstrated significant BDNF increases following exercise interventions. Successful interventions were characterized by neuromotor activities or martial arts programs, training frequencies ≥ 3 sessions/week, durations ≥ 12 weeks, and healthy participant populations. Methodological quality was mostly fair, with four studies rated as fair and one as good. Conclusions: Structured physical exercise may enhance BDNF levels in healthy children, with neuromotor activities and martial arts showing particular promise. However, children with overweight/obesity may require modified intervention approaches. The evidence supports the implementation of cognitively engaging physical activities in educational settings to optimize brain health during critical developmental periods, though larger standardized trials are needed to strengthen these preliminary findings.
000162722 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000162722 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162722 700__ $$aGonzález-Devesa, Daniel
000162722 700__ $$0(orcid)0000-0002-4084-8124$$aGómez-Carmona, Carlos D.$$uUniversidad de Zaragoza
000162722 700__ $$aMoreno-Villanueva, Adrián
000162722 7102_ $$13001$$2187$$aUniversidad de Zaragoza$$bDpto. Expres.Music.Plást.Corp.$$cÁrea Didáctica Expres.Corporal
000162722 773__ $$g15, 7 (2025), 1147 [15 pp.]$$pLife (Basel)$$tLife$$x2075-1729
000162722 8564_ $$s417714$$uhttps://zaguan.unizar.es/record/162722/files/texto_completo.pdf$$yVersión publicada
000162722 8564_ $$s2472466$$uhttps://zaguan.unizar.es/record/162722/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162722 909CO $$ooai:zaguan.unizar.es:162722$$particulos$$pdriver
000162722 951__ $$a2025-10-17-14:14:31
000162722 980__ $$aARTICLE