000162725 001__ 162725
000162725 005__ 20251017144613.0
000162725 0247_ $$2doi$$a10.1523/JNEUROSCI.0453-25.2025
000162725 0248_ $$2sideral$$a145290
000162725 037__ $$aART-2025-145290
000162725 041__ $$aeng
000162725 100__ $$aAbbagnano, Emanuele
000162725 245__ $$aProjection of Cortical Beta Band Oscillations to a Motor Neuron Pool across the Full Range of Recruitment
000162725 260__ $$c2025
000162725 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162725 5203_ $$aCortical beta band oscillations (13–30 Hz) are associated with sensorimotor control, but their precise role remains unclear. Evidence suggests that for low-threshold motor neurons (MNs), these oscillations are conveyed to muscles via the fastest corticospinal fibers. However, their transmission to MNs of different sizes may vary due to differences in the relative strength of corticospinal and reticulospinal projections across the MN pool. Consequently, it remains uncertain whether corticospinal beta transmission follows similar pathways and maintains consistent strength across the entire MN pool. To investigate this, we examined beta activity in MNs innervating the tibialis anterior muscle across the full range of recruitment thresholds in a study involving 12 participants of both sexes. We characterized beta activity at both the cortical and motor unit (MU) levels, while participants performed contractions from mild to submaximal levels. Corticomuscular coherence remained unchanged across contraction forces after normalizing for the net MU spike rate, suggesting that beta oscillations are transmitted with similar strength to MNs, regardless of size. To further explore beta transmission, we estimated corticospinal delays using the cumulant density function, identifying peak correlations between cortical and muscular activity. Once compensated for variable peripheral axonal propagation delay across MNs, the corticospinal delay remained stable, and its value (∼14 ms) indicated projections through the fastest corticospinal fibers for all MNs. These findings demonstrate that corticospinal beta band transmission is determined by the fastest pathway connecting in the corticospinal tract, projecting similarly across the entire MN pool.
000162725 536__ $$9info:eu-repo/grantAgreement/EC/HORIZON EUROPE/101077693/EU/Extracting the Human Motor Null Space from Muscles - A new framework to measure human neural activity/ECHOES
000162725 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000162725 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162725 700__ $$aPascual-Valdunciel, Alejandro
000162725 700__ $$aZicher, Blanka
000162725 700__ $$0(orcid)0000-0001-8439-151X$$aIbañez, Jaime$$uUniversidad de Zaragoza
000162725 700__ $$aFarina, Dario
000162725 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000162725 773__ $$g45, 31 (2025), e0453252025 [12 pp.]$$pJ. neurosci.$$tJOURNAL OF NEUROSCIENCE$$x0270-6474
000162725 8564_ $$s1628790$$uhttps://zaguan.unizar.es/record/162725/files/texto_completo.pdf$$yVersión publicada
000162725 8564_ $$s2804778$$uhttps://zaguan.unizar.es/record/162725/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162725 909CO $$ooai:zaguan.unizar.es:162725$$particulos$$pdriver
000162725 951__ $$a2025-10-17-14:18:22
000162725 980__ $$aARTICLE