000162740 001__ 162740
000162740 005__ 20251017144621.0
000162740 0247_ $$2doi$$a10.1002/cam4.71173
000162740 0248_ $$2sideral$$a145212
000162740 037__ $$aART-2025-145212
000162740 041__ $$aeng
000162740 100__ $$aRubio-Briones, J.
000162740 245__ $$aReal World Evidence of Active Surveillance for Prostate Cancer in Spain; Midterm Results
000162740 260__ $$c2025
000162740 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162740 5203_ $$aABSTRACTPatients and MethodsIn this multicenter longitudinal study, data from the Spanish Register in AS (AEU‐PIEM/2014/0001) were reviewed. The study focused on a cohort of AS patients registered between 2014 and 2019, featuring open inclusion criteria and diverse follow‐up strategies.ResultsA total of 3315 AS patients were recruited, with 2881 and 434 categorized into the low and intermediate risk groups based on NCCN grouping at inclusion. The median age was 67 years, and only 11% underwent diagnostic biopsy guided by MRI. The median time between follow‐up visits was 6.03 months. Over a median follow‐up of 62 months (Q1–3: 43.78–85.58), 37% remained in AS, while 8% transitioned to watchful waiting due to aging or intercurrent disease. Death occurred in 199 (6%) of patients, with 3 due to prostate cancer progression and 196 attributed to other causes. At 2 and 5 years, pathological progression‐free survival, metastasis‐free survival, and active treatment‐free survival were 68% and 51%, 99% and 99%, and 70% and 50%, respectively.ConclusionsMidterm oncological outcomes of AS in Spain align with major international series. We denote underuse of guideline recommendations such as use of MRI or TP Bx for initial PCa characterization. Collaborative efforts are crucial in the search for algorithms, new imaging, or biomarkers to refine indications and transition to active treatments.Trial RegistrationClinicalTrials.gov identifier: NCT02865330
000162740 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T69-23R$$9info:eu-repo/grantAgreement/ES/MICINN/PID2023-150234NB-I00
000162740 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000162740 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162740 700__ $$0(orcid)0000-0003-0178-4567$$aBorque-Fernando, A.$$uUniversidad de Zaragoza
000162740 700__ $$0(orcid)0000-0002-3007-302X$$aEsteban Escaño, L.M.
000162740 700__ $$aWong, A.
000162740 700__ $$aGuijarro Cascales, A.
000162740 700__ $$aGómez Gómez, E.
000162740 700__ $$0(orcid)0000-0002-5629-7646$$aGil Fabra, J.M.$$uUniversidad de Zaragoza
000162740 700__ $$aSanguedolce, F.
000162740 700__ $$aGomez-Veiga, F.
000162740 700__ $$aLópez González, P.A.
000162740 700__ $$aPlata Bello, A.
000162740 700__ $$aRodríguez García, N.
000162740 700__ $$aMontesino Semper, M.
000162740 700__ $$aSuárez Novo, J.F.
000162740 700__ $$aHajianfar, R.
000162740 700__ $$aFumadó Ciutat, L.l.
000162740 700__ $$aGonzález Alfaro, A.
000162740 700__ $$aDuarte Ojeda, J.M.
000162740 700__ $$aBono Ariño, A.
000162740 700__ $$aQuicios Dorado, C.
000162740 700__ $$aLoizaga Iriarte, A.
000162740 700__ $$aGarcía Fadrique, G.
000162740 700__ $$aGiménez Bachs, J.M.
000162740 700__ $$aGarcía Barreras, S.
000162740 700__ $$aPallas Costa, Y.
000162740 700__ $$aVilaseca Cabo, A.
000162740 700__ $$aRodrigo Aliaga, M.
000162740 700__ $$aCampanario Pérez, F.
000162740 700__ $$aServián, P.
000162740 700__ $$aCampá Bortoló, J. M.
000162740 700__ $$aSoto Delgado, M.
000162740 700__ $$aRodríguez de Ledesma, J.M.
000162740 700__ $$aSánchez Rodríguez, C.
000162740 700__ $$aChantada Abal, V.
000162740 700__ $$aHernández Martínez, Y.E.
000162740 700__ $$aHerrera Imbroda, B.
000162740 700__ $$aDolezal, P.
000162740 700__ $$aGual Frau, J.
000162740 700__ $$aMedrano Llorente, P.
000162740 700__ $$aMoreno Jiménez, J.
000162740 700__ $$aSerrano Uribe, J.S.
000162740 700__ $$aCongregado Ruiz, C.B.
000162740 700__ $$aReyes, A.
000162740 700__ $$aFernández Aparicio, T.
000162740 700__ $$aGarcía Rodríguez, J.
000162740 700__ $$aCuadras Solé, M.
000162740 700__ $$aGarcía Seguí, A.
000162740 700__ $$aPacheco Bru, J.J.
000162740 700__ $$aMayor de Castro, J.
000162740 700__ $$aMira Moreno, A.
000162740 700__ $$aMolina Suárez, J.L.
000162740 7102_ $$11013$$2817$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Urología
000162740 773__ $$g14, 17 (2025), e71173 [10 pp.]$$pCancer med.$$tCancer medicine$$x2045-7634
000162740 8564_ $$s2261312$$uhttps://zaguan.unizar.es/record/162740/files/texto_completo.pdf$$yVersión publicada
000162740 8564_ $$s2399727$$uhttps://zaguan.unizar.es/record/162740/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162740 909CO $$ooai:zaguan.unizar.es:162740$$particulos$$pdriver
000162740 951__ $$a2025-10-17-14:21:59
000162740 980__ $$aARTICLE