000162742 001__ 162742
000162742 005__ 20251017144621.0
000162742 0247_ $$2doi$$a10.3390/microorganisms13081771
000162742 0248_ $$2sideral$$a145222
000162742 037__ $$aART-2025-145222
000162742 041__ $$aeng
000162742 100__ $$aFernández-Carro, Estibaliz$$uUniversidad de Zaragoza
000162742 245__ $$aAlternatives Integrating Omics Approaches for the Advancement of Human Skin Models: A Focus on Metagenomics, Metatranscriptomics, and Metaproteomics
000162742 260__ $$c2025
000162742 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162742 5203_ $$aThe human skin microbiota, a complex community of bacterial, fungal, and viral organisms, plays a crucial role in maintaining skin homeostasis and regulating host-pathogen interactions. Dysbiosis within this microbial ecosystem has been implicated in various dermatological conditions, including acne vulgaris, psoriasis, seborrheic dermatitis, and atopic dermatitis. This review, for the first time, provides recent advancements in all four layers of omic technologies—metagenomics, metatranscriptomics, metaproteomics, and metabolomics—offering comprehensive insights into microbial diversity, in the context of functional skin modeling. Thus, this review explores the application of these omic tools to in vitro skin models, providing an integrated framework for understanding the molecular mechanisms underlying skin–microbiota interactions in both healthy and pathological contexts. We highlight the importance of developing advanced in vitro skin models, including the integration of immune components and endothelial cells, to accurately replicate the cutaneous microenvironment. Moreover, we discuss the potential of these models to identify novel therapeutic targets, enabling the design of personalized treatments aimed at restoring microbial balance, reinforcing the skin barrier, and modulating inflammation. As the field progresses, the incorporation of multi-omic approaches into skin-microbiome research will be pivotal in unraveling the complex interactions between host and microbiota, ultimately advancing therapeutic strategies for skin-related diseases.
000162742 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000162742 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162742 700__ $$aLetsiou, Sophia
000162742 700__ $$aTsironi, Stella
000162742 700__ $$aChaniotis, Dimitrios
000162742 700__ $$0(orcid)0000-0002-8666-622X$$aCiriza, Jesús$$uUniversidad de Zaragoza
000162742 700__ $$aBeloukas, Apostolos
000162742 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000162742 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana
000162742 773__ $$g13, 8 (2025), 1771 [13 pp.]$$pMicroorganisms$$tMicroorganisms$$x2076-2607
000162742 8564_ $$s525727$$uhttps://zaguan.unizar.es/record/162742/files/texto_completo.pdf$$yVersión publicada
000162742 8564_ $$s2548594$$uhttps://zaguan.unizar.es/record/162742/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162742 909CO $$ooai:zaguan.unizar.es:162742$$particulos$$pdriver
000162742 951__ $$a2025-10-17-14:22:00
000162742 980__ $$aARTICLE