000162767 001__ 162767
000162767 005__ 20251017144628.0
000162767 0247_ $$2doi$$a10.3390/plants14172678
000162767 0248_ $$2sideral$$a145217
000162767 037__ $$aART-2025-145217
000162767 041__ $$aeng
000162767 100__ $$aTrabelsi, Dhekra
000162767 245__ $$aSupercritical CO2 Antisolvent Fractionation of Citrus aurantium Flower Extracts: Enrichment and Characterization of Bioactive Compounds
000162767 260__ $$c2025
000162767 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162767 5203_ $$aThis study investigates the valorisation of sour orange (Citrus aurantium L.) flowers using supercritical antisolvent fractionation (SAF) with CO2 as an antisolvent. SAF was applied to selectively recover bioactive compounds from ethanolic extracts, using supercritical CO2 to induce precipitation. Response Surface Methodology (RSM) was employed to optimize operational conditions across a pressure range of 8.7–15 MPa and CO2 flow rates of 0.6–1.8 kg/h, at a constant temperature of 40 °C. Pressure showed a statistically significant positive effect on precipitate yield, while higher CO2 flow rates led to reduced recovery. High-performance liquid chromatography (HPLC) analysis identified naringin (33.7%), neohesperidin (21.6%), and synephrine (9.0%) as the main components of the enriched fractions. SAF enabled the selective concentration of these compounds, supporting its application as a green separation technique. As a complementary evaluation, preliminary in silico predictions of ADMET properties and skin permeability were performed. The results indicated favourable absorption, low predicted toxicity, and limited dermal permeation for the major flavonoids. These findings are consistent with available experimental and regulatory safety data. Overall, the study demonstrates the potential of SAF as an effective green technology for the selective extraction and enrichment of high-value bioactive compounds derived from Citrus aurantium flowers, with promising applications in cosmetic, nutraceutical, and pharmaceutical formulations.
000162767 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E39-23R
000162767 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000162767 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162767 700__ $$0(orcid)0000-0001-6182-2196$$aMartínez-López, José F.$$uUniversidad de Zaragoza
000162767 700__ $$aAbderrabba, Manef
000162767 700__ $$0(orcid)0000-0001-7569-5036$$aUrieta, José S.$$uUniversidad de Zaragoza
000162767 700__ $$0(orcid)0000-0001-9379-8047$$aMainar, Ana M.$$uUniversidad de Zaragoza
000162767 7102_ $$12012$$2755$$aUniversidad de Zaragoza$$bDpto. Química Física$$cÁrea Química Física
000162767 773__ $$g14, 17 (2025), 2678 [19 pp.]$$tPlants$$x2223-7747
000162767 8564_ $$s1196708$$uhttps://zaguan.unizar.es/record/162767/files/texto_completo.pdf$$yVersión publicada
000162767 8564_ $$s2519471$$uhttps://zaguan.unizar.es/record/162767/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162767 909CO $$ooai:zaguan.unizar.es:162767$$particulos$$pdriver
000162767 951__ $$a2025-10-17-14:25:16
000162767 980__ $$aARTICLE