Repositorio Institucional de Documentos

000162833 001__ 162833
000162833 005__ 20251017144653.0
000162833 0247_ $$2doi$$a10.1002/cssc.202501255
000162833 0248_ $$2sideral$$a145381
000162833 037__ $$aART-2025-145381
000162833 041__ $$aeng
000162833 100__ $$aPerulli, Stefania
000162833 245__ $$aThree‐Step One‐Pot Photocatalytic Oxidation of Feedstocks and Organocatalytic Sequential Cascade to Access Enantioenriched α‐Aminonitriles
000162833 260__ $$c2025
000162833 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162833 5203_ $$aA three‐step, one‐pot, sequential cascade starting from simple feedstocks to increase complexity toward value‐added chiral synthetic building blocks is reported. This is achieved by precisely integrating organic photocatalysis and noncovalent organocatalysis, often operating at dissimilar conditions and reaction media. In particular, this strategy is used to enable the direct transformation of readily available benzylic substrates, such as methylbenzenes, benzyl alcohols, or amines, into enantioenriched α‐aminonitriles by benzylic CH photooxidation to their corresponding aldehydes, followed by in situ imine formation and final asymmetric organocatalytic Strecker reaction. The enantioenriched α‐aminonitrile products are built in moderate to good yields and moderate to high enantiomeric ratios (up to 96:4 e.r.), highlighting the effectiveness of the overall cascade process. This methodology simplifies complex synthetic pathways, enhances atom economy, and broadens the applicability of metal‐free photocatalytic methodologies, offering a robust platform for constructing chiral building blocks from abundant starting materials and feedstocks.
000162833 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2020-117455GB-I00$$9info:eu-repo/grantAgreement/ES/AEI/PID2023-147471NB-I00$$9info:eu-repo/grantAgreement/ES/DGA/E07-23R
000162833 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000162833 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162833 700__ $$0(orcid)0000-0002-0904-9180$$aArdevines, Sandra$$uUniversidad de Zaragoza
000162833 700__ $$aMalagón, Sara
000162833 700__ $$aKhassenova, Gaukhar
000162833 700__ $$aHülße, Timo
000162833 700__ $$0(orcid)0000-0001-6832-8983$$aMarqués-López, Eugenia$$uUniversidad de Zaragoza
000162833 700__ $$0(orcid)0000-0002-5244-9569$$aPérez Herrera, Raquel
000162833 700__ $$aGarcía Mancheño, Olga
000162833 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000162833 773__ $$g(2025), [6 pp.]$$pChemSusChem$$tChemSusChem$$x1864-5631
000162833 8564_ $$s884851$$uhttps://zaguan.unizar.es/record/162833/files/texto_completo.pdf$$yVersión publicada
000162833 8564_ $$s2869505$$uhttps://zaguan.unizar.es/record/162833/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162833 909CO $$ooai:zaguan.unizar.es:162833$$particulos$$pdriver
000162833 951__ $$a2025-10-17-14:37:12
000162833 980__ $$aARTICLE