162833 20251017144653.0 doi 10.1002/cssc.202501255 sideral 145381 ART-2025-145381 eng Perulli, Stefania Three‐Step One‐Pot Photocatalytic Oxidation of Feedstocks and Organocatalytic Sequential Cascade to Access Enantioenriched α‐Aminonitriles 2025 Access copy available to the general public Unrestricted A three‐step, one‐pot, sequential cascade starting from simple feedstocks to increase complexity toward value‐added chiral synthetic building blocks is reported. This is achieved by precisely integrating organic photocatalysis and noncovalent organocatalysis, often operating at dissimilar conditions and reaction media. In particular, this strategy is used to enable the direct transformation of readily available benzylic substrates, such as methylbenzenes, benzyl alcohols, or amines, into enantioenriched α‐aminonitriles by benzylic CH photooxidation to their corresponding aldehydes, followed by in situ imine formation and final asymmetric organocatalytic Strecker reaction. The enantioenriched α‐aminonitrile products are built in moderate to good yields and moderate to high enantiomeric ratios (up to 96:4 e.r.), highlighting the effectiveness of the overall cascade process. This methodology simplifies complex synthetic pathways, enhances atom economy, and broadens the applicability of metal‐free photocatalytic methodologies, offering a robust platform for constructing chiral building blocks from abundant starting materials and feedstocks. info:eu-repo/grantAgreement/ES/AEI/PID2020-117455GB-I00 info:eu-repo/grantAgreement/ES/AEI/PID2023-147471NB-I00 info:eu-repo/grantAgreement/ES/DGA/E07-23R info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ardevines, Sandra Universidad de Zaragoza (orcid)0000-0002-0904-9180 Malagón, Sara Khassenova, Gaukhar Hülße, Timo Marqués-López, Eugenia Universidad de Zaragoza (orcid)0000-0001-6832-8983 Pérez Herrera, Raquel (orcid)0000-0002-5244-9569 García Mancheño, Olga 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica (2025), [6 pp.] ChemSusChem ChemSusChem 1864-5631 884851 http://zaguan.unizar.es/record/162833/files/texto_completo.pdf Versión publicada 2869505 http://zaguan.unizar.es/record/162833/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:162833 articulos driver 2025-10-17-14:37:12 ARTICLE