000162877 001__ 162877 000162877 005__ 20251017144550.0 000162877 0247_ $$2doi$$a10.1111/sms.70133 000162877 0248_ $$2sideral$$a145424 000162877 037__ $$aART-2025-145424 000162877 041__ $$aeng 000162877 100__ $$0(orcid)0000-0002-2854-6684$$aAra, Ignacio 000162877 245__ $$aExercise as a Therapy for Successful Aging 000162877 260__ $$c2025 000162877 5060_ $$aAccess copy available to the general public$$fUnrestricted 000162877 5203_ $$aRegular physical activity has profound and multifaceted benefits for individuals as they age. This review highlights the role of exercise in promoting healthy and successful aging, emphasizing its effectiveness in the prevention and treatment of frailty and disability. Exercise is a primary intervention to attenuate the age‐related biological and functional decline by targeting mainly the cardiorespiratory, vascular, nervous, and skeletal muscle systems. From a biological perspective, we review the evidence on the role of exercise in mitigating the three categories of the biological hallmarks of aging: primary, antagonistic, and integrative. Different types of exercise may elicit different benefits for older adults. Thus, our review also emphasizes the importance of incorporating tailored and personalized exercise programs that align with individual health profiles and conditions, ranging from geriatric care to senior athletes. We also review the benefits that multicomponent exercise interventions, that combine power‐oriented resistance training with high‐intensity interval training, have for improving health outcomes in older adults. Overcoming the barriers that deter older adults from exercising requires a comprehensive approach that addresses psychological, economic, social, environmental, and gender perspective factors to increase participation. Governments play a key role by applying evidence‐based strategies, offering accessible exercise programs, creating supportive environments, and promoting policies that strengthen older adults' motivation and autonomy. These measures should ensure that all older adults have the same opportunities to engage in exercise, ultimately fostering healthier societies. 000162877 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2022-142470OB-I00$$9info:eu-repo/grantAgreement/ES/AEI/RED2022-134800-T$$9info:eu-repo/grantAgreement/ES/ISCIII/CB16-10-00435$$9info:eu-repo/grantAgreement/ES/ISCIII/CB16-10-00477 000162877 540__ $$9info:eu-repo/semantics/embargoedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000162877 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000162877 700__ $$aGómez-Cabrera, María Carmen 000162877 700__ $$0(orcid)0000-0001-8374-9081$$aGaratachea, Nuria$$uUniversidad de Zaragoza 000162877 7102_ $$11006$$2245$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Educación Física y Depor. 000162877 773__ $$g35, 9 (2025), e70133 [34 pp.]$$pScand. j. med. sci. sports$$tScandinavian Journal of Medicine and Science in Sports$$x0905-7188 000162877 8564_ $$s810738$$uhttps://zaguan.unizar.es/record/162877/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2026-08-30 000162877 8564_ $$s1848430$$uhttps://zaguan.unizar.es/record/162877/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2026-08-30 000162877 909CO $$ooai:zaguan.unizar.es:162877$$particulos$$pdriver 000162877 951__ $$a2025-10-17-14:11:42 000162877 980__ $$aARTICLE