000162881 001__ 162881
000162881 005__ 20251017144551.0
000162881 0247_ $$2doi$$a10.1016/j.psyneuen.2019.05.024
000162881 0248_ $$2sideral$$a114490
000162881 037__ $$aART-2019-114490
000162881 041__ $$aeng
000162881 100__ $$aMontoliu, Teresa
000162881 245__ $$aThe relationship between loneliness and cognition in healthy older men and women: The role of cortisol
000162881 260__ $$c2019
000162881 5203_ $$aLoneliness has been associated with an increased risk of cognitive decline and dementia in older people, as well as a dysregulation of Hypothalamic–Pituitary–Adrenal (HPA) axis functioning. In addition, it has been suggested that women are more vulnerable to the negative effects of loneliness on health. Our aim was to analyze the effect of HPA-axis functioning as a mediator in the relationship between loneliness and cognitive function, and interactions depending on sex, in healthy older people. To do so, 86 healthy older people (52.3% female) from 60 to 80 years old (M = 67.44, SD = 4.37) completed the revised UCLA loneliness scale. A neuropsychological battery was administered to assess global cognition, processing speed, attention and executive function, working memory, and verbal memory immediate and delayed recall. Saliva samples were provided on two consecutive weekdays to obtain awakening and bedtime cortisol levels, the diurnal cortisol slope (DCS), and the area under the curve with respect to the ground (AUCg). Our results showed that loneliness was not directly associated with cognitive performance. Furthermore, loneliness was related to higher bedtime cortisol levels, but not to awakening cortisol, the DCS, or the AUCg. In addition, loneliness was associated with worse performance on attention and processing speed, executive function, and verbal memory immediate recall, via bedtime cortisol levels. Therefore, we suggest that HPA-axis functioning is one of the biological mechanisms that mediate the relationship between loneliness and poorer cognitive function. No sex differences were observed in these associations.
000162881 536__ $$9info:eu-repo/grantAgreement/ES/MEC/PSI2016-78763-P
000162881 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000162881 590__ $$a4.732$$b2019
000162881 591__ $$aENDOCRINOLOGY & METABOLISM$$b27 / 143 = 0.189$$c2019$$dQ1$$eT1
000162881 591__ $$aPSYCHIATRY$$b24 / 154 = 0.156$$c2019$$dQ1$$eT1
000162881 591__ $$aNEUROSCIENCES$$b57 / 270 = 0.211$$c2019$$dQ1$$eT1
000162881 592__ $$a2.049$$b2019
000162881 593__ $$aBiological Psychiatry$$c2019$$dQ1
000162881 593__ $$aEndocrine and Autonomic Systems$$c2019$$dQ1
000162881 593__ $$aPsychiatry and Mental Health$$c2019$$dQ1
000162881 593__ $$aEndocrinology, Diabetes and Metabolism$$c2019$$dQ1
000162881 593__ $$aEndocrinology$$c2019$$dQ1
000162881 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162881 700__ $$0(orcid)0000-0003-3920-1099$$aHidalgo, Vanesa$$uUniversidad de Zaragoza
000162881 700__ $$aSalvador, Alicia
000162881 7102_ $$14009$$2725$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicobiología
000162881 773__ $$g107 (2019), 270-279$$pPsychoneuroendocrinology$$tPSYCHONEUROENDOCRINOLOGY$$x0306-4530
000162881 8564_ $$s622951$$uhttps://zaguan.unizar.es/record/162881/files/texto_completo.pdf$$yVersión publicada
000162881 8564_ $$s2558155$$uhttps://zaguan.unizar.es/record/162881/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162881 909CO $$ooai:zaguan.unizar.es:162881$$particulos$$pdriver
000162881 951__ $$a2025-10-17-14:12:00
000162881 980__ $$aARTICLE