000162897 001__ 162897
000162897 005__ 20251017144603.0
000162897 0247_ $$2doi$$a10.3390/nu17172894
000162897 0248_ $$2sideral$$a145397
000162897 037__ $$aART-2025-145397
000162897 041__ $$aeng
000162897 100__ $$aGrasa-Ciria, Diego
000162897 245__ $$aDisrupted Rhythms, Disrupted Microbes: A Systematic Review of Shift Work and Gut Microbiota Alterations
000162897 260__ $$c2025
000162897 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162897 5203_ $$aBackground: Shift work, especially during nighttime hours, disrupts the circadian system and is linked to higher rates of metabolic, gastrointestinal, cardiovascular, and neurocognitive disorders. Emerging evidence suggests that gut microbiota may mediate these associations. This systematic review assessed whether shift work alters gut microbiota composition and explored potential health consequences. Methods: A systematic search was conducted in PubMed, Scopus, and ScienceDirect from inception to March 2025. Studies reporting gut microbiota alterations in adult shift workers were included. Two reviewers independently screened articles and extracted data. Risk of bias was assessed using the NIH Quality Assessment Tool and the ROBINS-E framework. Five studies met the eligibility criteria and were included in the final synthesis. Results: The selected studies comprised four observational investigations with small sample sizes and one Mendelian randomization study leveraging large-scale genetic datasets. Observational studies reported reduced α-diversity and increased relative abundance of pro-inflammatory genera—including Escherichia/Shigella, Blautia, and Dialister—in night shift workers. These microbiota alterations were associated with gastrointestinal complaints and indicators of cardiometabolic dysfunction. The Mendelian randomization study provided preliminary evidence supporting a causal relationship between circadian misalignment, gut dysbiosis, and increased cardiovascular risk. Conclusions: Shift work is associated with significant alterations in gut microbiota composition that may contribute to adverse health outcomes. However, current evidence is limited and heterogeneous, preventing firm causal conclusions. Further high-quality longitudinal and interventional research is needed to clarify underlying mechanisms and inform preventive strategies.
000162897 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000162897 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162897 700__ $$aCouto, Sergio$$uUniversidad de Zaragoza
000162897 700__ $$aSamatán, Eva
000162897 700__ $$0(orcid)0000-0001-6469-9189$$aMartínez-Jarreta, Begoña$$uUniversidad de Zaragoza
000162897 700__ $$aCenit, María del Carmen
000162897 700__ $$0(orcid)0000-0003-4242-5464$$aIguacel, Isabel$$uUniversidad de Zaragoza
000162897 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000162897 7102_ $$11012$$2613$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Medicina Legal y Forense
000162897 773__ $$g17, 17 (2025), 2894 [16 pp.]$$pNutrients$$tNutrients$$x2072-6643
000162897 8564_ $$s664739$$uhttps://zaguan.unizar.es/record/162897/files/texto_completo.pdf$$yVersión publicada
000162897 8564_ $$s2568902$$uhttps://zaguan.unizar.es/record/162897/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162897 909CO $$ooai:zaguan.unizar.es:162897$$particulos$$pdriver
000162897 951__ $$a2025-10-17-14:14:32
000162897 980__ $$aARTICLE