000162985 001__ 162985
000162985 005__ 20251009133839.0
000162985 0247_ $$2doi$$a10.1016/j.ijpharm.2020.119067
000162985 0248_ $$2sideral$$a116866
000162985 037__ $$aART-2020-116866
000162985 041__ $$aeng
000162985 100__ $$0(orcid)0000-0002-0595-5514$$aGarcía-Salinas, S.$$uUniversidad de Zaragoza
000162985 245__ $$aElectrospun anti-inflammatory patch loaded with essential oils for wound healing
000162985 260__ $$c2020
000162985 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162985 5203_ $$aWound healing is a complex process that consists of three overlapping phases: inflammation, proliferation, and remodeling. A bacterial infection can increase inflammation and delay this process. Microorganisms are closely related to the innate immune system, such as macrophages and neutrophils, as they can start an inflammatory cascade. Essential oils play an important role in the inhibition and prevention of bacterial growth due to their ability to reduce antimicrobial resistance. The possibility to find a strategy that combines antimicrobial and anti-inflammatory properties is particularly appealing for wound healing. In this work, we showcase a variety of patches based on electrospun polycaprolactone (PCL) nanofibers loaded with natural compounds derived from essential oils, such as thymol (THY) and tyrosol (TYR), to achieve reduced inflammation. In addition, we compared the effect these essential oils have on activated macrophages when incorporated into the PCL patch. Specifically, we demonstrate that PCL-THY resulted in more efficient down-regulation of pro-inflammatory genes related to the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-¿b) pathway when compared to PCL-TYR and the combination patch containing TYR and THY (i.e., PCL-TYR-THY). Furthermore, PCL-THY displayed low affinity for cell attachment, which may hinder wound adherence and integration. Overall, our results indicate that THY-loaded patches could serve as promising candidates for the fabrication of dressings that incorporate bactericidal and anti-inflammatory properties while simultaneously avoiding the limitations of traditional antibiotic-loaded devices.
000162985 536__ $$9info:eu-repo/grantAgreement/EUR/ERC-2013-CoG-614715$$9info:eu-repo/grantAgreement/ES/MCIU/BES-2015-073735$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2014-52384-R
000162985 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000162985 590__ $$a5.875$$b2020
000162985 591__ $$aPHARMACOLOGY & PHARMACY$$b37 / 275 = 0.135$$c2020$$dQ1$$eT1
000162985 592__ $$a1.153$$b2020
000162985 593__ $$aPharmaceutical Science$$c2020$$dQ1
000162985 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000162985 700__ $$aEvangelopoulos, M.
000162985 700__ $$0(orcid)0000-0002-0272-3152$$aGámez-Herrera, E.
000162985 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, M.$$uUniversidad de Zaragoza
000162985 700__ $$0(orcid)0000-0002-2966-9088$$aIrusta, S.$$uUniversidad de Zaragoza
000162985 700__ $$aTaraballi, F.
000162985 700__ $$0(orcid)0000-0003-2293-363X$$aMendoza, G.$$uUniversidad de Zaragoza
000162985 700__ $$aTasciotti, E.
000162985 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000162985 7102_ $$15005$$2790$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Tecnologi. Medio Ambiente
000162985 773__ $$g577 (2020), 119067 [14 pp.]$$pInt. j. pharm.$$tInternational Journal of Pharmaceutics$$x0378-5173
000162985 8564_ $$s4391303$$uhttps://zaguan.unizar.es/record/162985/files/texto_completo.pdf$$yPostprint
000162985 8564_ $$s1129019$$uhttps://zaguan.unizar.es/record/162985/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000162985 909CO $$ooai:zaguan.unizar.es:162985$$particulos$$pdriver
000162985 951__ $$a2025-10-09-13:25:42
000162985 980__ $$aARTICLE