000162987 001__ 162987
000162987 005__ 20251009133841.0
000162987 0247_ $$2doi$$a10.1002/mnfr.70223
000162987 0248_ $$2sideral$$a145479
000162987 037__ $$aART-2025-145479
000162987 041__ $$aeng
000162987 100__ $$0(orcid)0000-0002-8100-5596$$aMartínez-Beamonte, Roberto$$uUniversidad de Zaragoza
000162987 245__ $$aEffect of Extra Virgin Olive Oil High in Bioactive Compounds on Atherosclerosis in Apoe‐Deficient Mice
000162987 260__ $$c2025
000162987 5060_ $$aAccess copy available to the general public$$fUnrestricted
000162987 5203_ $$aTo test the effects of extra virgin olive oil (EVOO) enriched in specific bioactive compounds (EVOO HBC) on atherosclerosis and fatty liver, three isocaloric Western diets differing in the type of fat (palm, EVOO, or EVOO HBC) were fed to Apoe‐deficient mice for 12 weeks. Plasma lipids, lipoprotein characterization, circulating CD36‐expressing monocytes, and M2 peritoneal macrophages were quantified. Hepatic squalene and cross‐sectional and en face atherosclerotic lesions were analyzed. Compared to the palm group, plasma triglyceride and glucose levels increased, while APOA1, paraoxonase 1 activity, and lipoprotein oxidation decreased in mice fed both EVOO groups. The latter stored liver squalene according to the amount consumed. En face and cross‐sectional atherosclerotic lesions were lower in the EVOO groups. CD36 expression in circulating monocytes was lower and M2 peritoneal macrophages were higher in the EVOO groups. In males, there was a reduced presence of CD68‐expressing cells in atherosclerotic plaques, while in females, there was a reduction in en face lesions that negatively correlated with high‐density lipoprotein (HDL)‐phospholipid efflux. The recruitment of macrophages into atherosclerotic plaques and the improvement of HDL efflux may be sex‐dependent and attributable to the high content of squalene and a specific oleuropein aglycone.
000162987 536__ $$9info:eu-repo/grantAgreement/ES/CIBERObn/CB06-03-1012$$9info:eu-repo/grantAgreement/ES/DGA/B16-23R$$9info:eu-repo/grantAgreement/ES/MICINN-AEI/PRTR-C17.I1$$9info:eu-repo/grantAgreement/ES/MCINN/PID2022-136414OB-I00$$9info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG/NEWPOWER-S1-1.1-E01116
000162987 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000162987 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000162987 700__ $$0(orcid)0000-0002-8442-8041$$aBarranquero, Cristina
000162987 700__ $$aSoler, Laura
000162987 700__ $$aHerrero-Continente, Tania
000162987 700__ $$aRondón, Anny Carolina
000162987 700__ $$aArnal, Carmen
000162987 700__ $$aEstopañán, Gloria
000162987 700__ $$aLasheras, Roberto
000162987 700__ $$0(orcid)0000-0002-3595-7668$$aRodriguez-Yoldi, María Jesús$$uUniversidad de Zaragoza
000162987 700__ $$0(orcid)0000-0002-5841-0462$$aSurra, Joaquín Carlos
000162987 700__ $$aMartín-Belloso, Olga
000162987 700__ $$aOdriozola-Serrano, Isabel
000162987 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, Jesús$$uUniversidad de Zaragoza
000162987 700__ $$0(orcid)0000-0002-0108-1004$$aNavarro, María Ángeles$$uUniversidad de Zaragoza
000162987 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000162987 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000162987 773__ $$g(2025), e70223 [13 pp.]$$pMOL NUTR FOOD RES$$tMOLECULAR NUTRITION & FOOD RESEARCH$$x1613-4125
000162987 8564_ $$s1443203$$uhttps://zaguan.unizar.es/record/162987/files/texto_completo.pdf$$yVersión publicada
000162987 8564_ $$s2408598$$uhttps://zaguan.unizar.es/record/162987/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000162987 909CO $$ooai:zaguan.unizar.es:162987$$particulos$$pdriver
000162987 951__ $$a2025-10-09-13:25:56
000162987 980__ $$aARTICLE